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Manganese dioxide nanosheets: from preparation to biomedical applications

Authors Wu M, Hou P, Dong L, Cai L, Chen Z, Zhao M, Li J

Received 5 March 2019

Accepted for publication 23 May 2019

Published 3 July 2019 Volume 2019:14 Pages 4781—4800

DOI https://doi.org/10.2147/IJN.S207666

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Muyu Wu,*,1,2 Pingfu Hou*,3, Lina Dong,1 Lulu Cai,1 Zhudian Chen,1 Mingming Zhao,1 Jingjing Li1–2,4

1School of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, Jiangsu, People’s Republic of China; 2Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, Jiangsu, People’s Republic of China; 3Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou 221004, Jiangsu, People’s Republic of China; 4Institute of Medical Imaging and Digital Medicine, Xuzhou Medical University, Xuzhou 221004, Jiangsu, People’s Republic of China

*These authors contributed equally to this work

Abstract: Advancements in nanotechnology and molecular biology have promoted the development of a diverse range of models to intervene in various disorders (from diagnosis to treatment and even theranostics). Manganese dioxide nanosheets (MnO2 NSs), a typical two-dimensional (2D) transition metal oxide of nanomaterial that possesses unique structure and distinct properties have been employed in multiple disciplines in recent decades, especially in the field of biomedicine, including biocatalysis, fluorescence sensing, magnetic resonance imaging and cargo-loading functionality. A brief overview of the different synthetic methodologies for MnO2 NSs and their state-of-the-art biomedical applications is presented below, as well as the challenges and future perspectives of MnO2 NSs.

Keywords: MnO2 nanosheets, synthetic methods, biocatalysis, fluorescence sensing, controlled drug delivery, stimuli-activated imaging


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