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Managing dialysis patients who develop anemia caused by chronic kidney disease: focus on peginesatide

Authors Valliant A, Hofmann RM

Received 8 March 2013

Accepted for publication 10 May 2013

Published 26 August 2013 Volume 2013:8(1) Pages 3297—3307

DOI https://doi.org/10.2147/IJN.S44944

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Amanda Valliant, R Michael Hofmann

Division of Nephrology, University of Wisconsin, Madison, WI, USA

Abstract: Anemia in chronic kidney disease is a prevalent and expensive problem in the United States, and it is well documented that anemia worsens as glomerular filtration rates decline. The complications of severe anemia in this patient population contribute significantly to their overall morbidity with increased cardiovascular complications, decreased quality of life, and increased dependence on transfusions to maintain adequate hemoglobin levels. Erythropoietin-stimulating agents (ESAs) have revolutionized the treatment of anemia in this population, but there has been a great deal of controversy surrounding the quest for the ideal hemoglobin target. In addition, there are economic and practice management implications where anemia treatment is concerned, with ongoing refinement of Centers for Medicare and Medicaid Services-bundled payments. One of the newest additions to the arsenal used to fight anemia in end-stage renal disease patients is peginesatide (Omontys), a synthetic, PEGylated, peptide-based ESA that acts by stimulating the erythropoietin receptor. The role of peginesatide in the future treatment of anemia in chronic kidney disease remains uncertain, with new safety concerns being brought to attention as it emerges on the market, prompting a national recall.

Keywords: anemia, chronic kidney disease, peginesatide

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