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Managing comorbidities in idiopathic pulmonary fibrosis

Authors Fulton B, Ryerson C

Received 8 May 2015

Accepted for publication 25 August 2015

Published 22 September 2015 Volume 2015:8 Pages 309—318

DOI https://doi.org/10.2147/IJGM.S74880

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Editor who approved publication: Dr Scott Fraser


Blair G Fulton,1 Christopher J Ryerson1,2

1Department of Medicine, 2Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada

Abstract: Major risk factors for idiopathic pulmonary fibrosis (IPF) include older age and a history of smoking, which predispose to several pulmonary and extra-pulmonary diseases. IPF can be associated with additional comorbidities through other mechanisms as either a cause or a consequence of these diseases. We review the literature regarding the management of common pulmonary and extra-pulmonary comorbidities, including chronic obstructive pulmonary disease, lung cancer, pulmonary hypertension, venous thromboembolism, sleep-disordered breathing, gastroesophageal reflux disease, coronary artery disease, depression and anxiety, and deconditioning. Recent studies have provided some guidance on the management of these diseases in IPF; however, most treatment recommendations are extrapolated from studies of non-IPF patients. Additional studies are required to more accurately determine the clinical features of these comorbidities in patients with IPF and to evaluate conventional treatments and management strategies that are beneficial in non-IPF populations.

Keywords: interstitial lung disease, management, idiopathic pulmonary fibrosis, comorbidities

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