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Management of severe sepsis: advances, challenges, and current status

Authors Martin-loeches I, Levy M, Artigas A

Received 5 December 2014

Accepted for publication 9 January 2015

Published 9 April 2015 Volume 2015:9 Pages 2079—2088

DOI https://doi.org/10.2147/DDDT.S78757

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Shu-Feng Zhou


Ignacio Martin-Loeches,1 Mitchell M Levy,2 Antonio Artigas3

1Multidisciplinary Intensive Care Research Organization (MICRO), St James’s University Hospital, Trinity Centre for Health Sciences, Dublin, Ireland; 2Brown University, Providence, RI, USA; 3Critical Care Center, CIBER Enfermedades Respiratorias, Sabadell Hospital, Corporació Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Barcelona, Spain

Abstract: The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.

Keywords: sepsis, septic shock, guidelines, critical care, biomarkers, surviving sepsis campaign

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