Back to Journals » International Journal of General Medicine » Volume 12

Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature

Authors Kosmidis C, Sapalidis K, Tsakalidis A, Atmatzidis S, Michalopoulos N, Koimtzis G, Karayannopoulou G, Lypiridou S, Varsamis N, Kouklakis G, Baka S, Zarogoulidis P, Kesisoglou I

Received 9 November 2018

Accepted for publication 22 January 2019

Published 1 March 2019 Volume 2019:12 Pages 121—124

DOI https://doi.org/10.2147/IJGM.S193988

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Christopher Kosmidis,1,2 Konstantinos Sapalidis,1 Alexandros Tsakalidis,1 Stefanos Atmatzidis,1 Nikolaos Michalopoulos,1 Georgios Koimtzis,1 Georgia Karayannopoulou,3 Sofia Lypiridou,3 Nikolaos Varsamis,2 Georgios Kouklakis,2 Sofia Baka,2 Paul Zarogoulidis,1 Isaac Kesisoglou1

1Third Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Department of Oncology, Interbalkan Medical Center, Thessaloniki, Greece; 3Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. However, rectal GISTs represent only 5% of this category. We report a case of a rectal GIST treated with local excision after neoadjuvant therapy.
Case presentation: A 41-year-old male patient presented with anal bleeding. Colonoscopy revealed a mass located 5 cm from the anal verge. Histological examination showed a GIST with immunohistochemical positivity for CD117 and CD34. Transanal local excision was performed after neoadjuvant therapy.
Conclusion: Neoadjuvant immunotherapy for GISTs with unfavorable localization may facilitate local excision and avoid complications of more demanding operations.

Keywords: gastrointestinal stromal tumor, rectal, neoadjuvant therapy, transanal excision

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]