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Management of HIV/AIDS in older patients–drug/drug interactions and adherence to antiretroviral therapy

Authors Burgess M, Zeuli JD, Kasten MJ

Received 3 November 2014

Accepted for publication 9 February 2015

Published 27 October 2015 Volume 2015:7 Pages 251—264

DOI https://doi.org/10.2147/HIV.S39655

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Shenghan Lai


Mary J Burgess,1 John D Zeuli,2 Mary J Kasten3

1Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Department of Pharmacy, Mayo Clinic, Rochester, MN, USA; 3Divisions of General Internal Medicine and Infectious Diseases, Mayo Clinic, Rochester, MN, USA

Abstract: Patients with human immunodeficiency virus (HIV) are living longer with their disease, as HIV has become a chronic illness managed with combination antiretroviral therapy (cART). This has led to an increasing number of patients greater than 50 years old living successfully with HIV. As the number of older adults with HIV has increased, there are special considerations for the management of HIV. Older adults with HIV must be monitored for drug side effects and toxicities. Their other non-HIV comorbidities should also be considered when choosing a cART regimen. Older adults with HIV have unique issues related to medication compliance. They are more likely than the younger HIV patients to have vision loss, cognitive impairment, and polypharmacy. They may have lower expectations of their overall health status. Depression and financial concerns, especially if they are on a fixed income, may also contribute to noncompliance in the aging HIV population.

Keywords: HIV, aging population, management issues, drug interactions, medication adherence

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