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Management of hemorrhage in gastrointestinal stromal tumors: a review

Authors Liu Q, Kong F, Zhou J, Dong M, Dong Q

Received 13 December 2017

Accepted for publication 31 January 2018

Published 12 April 2018 Volume 2018:10 Pages 735—743

DOI https://doi.org/10.2147/CMAR.S159689

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Leylah Drusbosky


Qi Liu,1 Fanmin Kong,1 Jianping Zhou,1 Ming Dong,1 Qi Dong2

1Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, China; 2Department of General Surgery, The People’s Hospital, China Medical University, Shenyang, China

Abstract: Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors. They originate from the wall of hollow viscera and may be found in any part of the digestive tract. The prognosis of patients with stromal tumors depends on various risk factors, including size, location, presence of mitotic figures, and tumor rupture. Emergency surgery is often required for stromal tumors with hemorrhage. The current literature suggests that stromal tumor hemorrhage indicates poor prognosis. Although the optimal treatment options for hemorrhagic GISTs are based on surgical experience, there remains controversy with regard to optimum postoperative management as well as the classification of malignant potential. This article reviews the biological characteristics, diagnostic features, prognostic factors, treatment, and postoperative management of GISTs with hemorrhage.

Keywords: GIST, hemorrhage of digestive tract, prognosis, targeted therapy

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