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Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

Authors Li JY, Horwitz S, Moskowitz A, Myskowski PL, Pulitzer M, Querfeld C

Received 15 November 2011

Accepted for publication 22 January 2012

Published 12 March 2012 Volume 2012:4 Pages 75—89

DOI https://doi.org/10.2147/CMAR.S9660

Review by Single-blind

Peer reviewer comments 3


Janet Y Li1, Steven Horwitz2, Alison Moskowitz2, Patricia L Myskowski3, Melissa Pulitzer4, Christiane Querfeld3

1College of Physicians and Surgeons, Columbia University, 2Department of Medicine, Lymphoma Service, 3Department of Medicine, Dermatology Service, 4Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Abstract: Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin), and pralatrexate in CTCL.

Keywords: novel targets, histone deacetylase inhibitors, pralatrexate, bortezomib, cutaneous T cell lymphoma

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