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Management of Autosomal Dominant Polycystic Kidney Disease (ADPKD) During Pregnancy: Risks and Challenges

Authors McBride L, Wilkinson C, Jesudason S

Received 6 January 2020

Accepted for publication 20 March 2020

Published 25 May 2020 Volume 2020:12 Pages 409—422


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Everett F. Magann

Lucy McBride,1 Catherine Wilkinson,2 Shilpanjali Jesudason2,3

1Women’s and Babies’ Division, Women’s and Children’s Hospital, Adelaide, SA, Australia; 2Central and Northern Adelaide Renal and Transplantation Services (CNARTS), Royal Adelaide Hospital, Adelaide, SA, Australia; 3Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia

Correspondence: Lucy McBride Email

Abstract: Autosomal dominant polycystic kidney disease (ADPKD) affects up to 1 in 1000 people. The disease is characterized by the progressive development of cysts throughout the renal parenchyma due to inherited pathogenic variants in genes including PKD1 or PKD2 and eventually leads to gradual loss of renal function, along with manifestations in other organ systems such as hepatic cysts and intracranial aneurysms. ADPKD management has advanced considerably in recent years due to genetic testing availability, pre-implantation genetic diagnosis technology and new therapeutic agents. Renal disease in pregnancy is recognised as an important risk factor for adverse maternal and fetal outcome. Women with ADPKD and health professionals face multiple challenges in optimising outcomes during the pre-pregnancy, pregnancy and post-partum periods.

Keywords: autosomal dominant polycystic kidney disease, chronic kidney disease, cystic kidney disease, pregnancy

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