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Magnetic resonance spectroscopy in Alzheimer’s disease

Authors Graff-Radford J, Kantarci K

Received 5 March 2013

Accepted for publication 3 April 2013

Published 16 May 2013 Volume 2013:9 Pages 687—696

DOI https://doi.org/10.2147/NDT.S35440

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Jonathan Graff-Radford,1 Kejal Kantarci2

1Department of Neurology, 2Department of Radiology, Mayo Clinic, Rochester, MN, USA

Abstract: Aging is the primary risk factor for dementia. With increasing life expectancy and aging populations worldwide, dementia is becoming one of the significant public health problems of the century. The most common pathology underlying dementia in older adults is Alzheimer’s disease. Proton magnetic resonance spectroscopy (MRS) may provide a window into the biochemical changes associated with the loss of neuronal integrity and other neurodegenerative pathology that involve the brain before the manifestations of cognitive impairment in patients who are at risk for Alzheimer’s disease. This review focuses on proton MRS studies in normal aging, mild cognitive impairment, and dementia, and how proton MRS metabolite levels may be potential biomarkers for early diagnosis of dementia-related pathologic changes in the brain.

Keywords: Alzheimer’s disease, magnetic resonance spectroscopy, mild cognitive impairment

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