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Magnetic particle imaging: kinetics of the intravascular signal in vivo

Authors Haegele J, Duschka RL, Graeser M, Schaecke C, Panagiotopoulos N, Lüdtke-Buzug K, Buzug TM, Barkhausen J, Vogt F

Received 26 February 2014

Accepted for publication 8 May 2014

Published 3 September 2014 Volume 2014:9(1) Pages 4203—4209


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Julian Haegele,1 Robert L Duschka,1 Matthias Graeser,2 Catharina Schaecke,1 Nikolaos Panagiotopoulos,1 Kerstin Lüdtke-Buzug,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt1

1Clinic for Radiology and Nuclear Medicine, 2Institute of Medical Engineering, University Hospital Schleswig Holstein, Lübeck, Schleswig-Holstein, Germany

Background: Magnetic particle imaging (MPI) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles (SPIO). Today, Resovist® is still the reference SPIO for MPI. The objective of this study was to evaluate the in vivo blood half-life of two different types of Resovist (one from Bayer Pharma AG, and one from I’rom Pharmaceutical Co Ltd) in MPI.
Methods: A Resovist concentration of 50 µmol/kg was injected into the ear artery of ten New Zealand White rabbits. Five animals received Resovist distributed by I’rom Pharmaceutical Co Ltd and five received Resovist by Bayer Pharma AG. Blood samples were drawn before and directly after injection of Resovist, at 5, 10, and 15 minutes, and then every 15 ­minutes until 120 minutes after the injection. The MPI signal of the blood samples was evaluated using magnetic particle spectroscopy.
Results: The average decline of the blood MPI signal from the two distributions differed significantly (P=0.0056). Resovist distributed by Bayer Pharma AG showed a slower decline of the MPI signal (39.7% after 5 minutes, 20.5% after 10 minutes, and 12.1% after 15 minutes) compared with Resovist produced by I’rom Pharmaceutical Co Ltd (20.4% after 5 minutes, 7.8% after 10 minutes, no signal above noise level after 15 minutes).
Conclusion: In MPI, the blood half-life of an SPIO tracer cannot be equalized to the blood half-life of its MPI signal. Resovist shows a very rapid decline of blood MPI signal and is thus not suitable as a long circulating tracer. For cardiovascular applications in MPI, it may be used as a bolus tracer.

Keywords: magnetic particle imaging, superparamagnetic iron oxide nanoparticles, magnetic particle spectroscopy, blood half-life time, Resovist®

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