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Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

Authors Wang Q, Liu S, Yang F, Gan L, Yang X, Yang Y

Received 28 December 2016

Accepted for publication 7 April 2017

Published 8 June 2017 Volume 2017:12 Pages 4335—4347


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun

Qin Wang,1 Shanshan Liu,1 Fan Yang,2 Lu Gan,3 Xiangliang Yang,3 Yajiang Yang1

1National Engineering Research Center for Nanomedicine, School of Chemistry and Chemical Engineering, 2Department of Radiology, Union Hospital, Tongji Medical College, 3National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

Abstract: Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres. The release behavior of dual drugs from the microspheres show typical sustained release profiles. As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized.

Keywords: MRI visuality, chemoembolization, microfluidics, dual drugs, alginate micro­spheres

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