Back to Journals » International Journal of General Medicine » Volume 13

MAGGIC Risk Model Predicts Adverse Events and Left Ventricular Remodeling in Non-Ischemic Dilated Cardiomyopathy

Authors Dong Y, Wang D, Lv J, Pan Z, Xu R, Ding J, Cui X, Xie X, Guo X

Received 26 October 2020

Accepted for publication 18 November 2020

Published 10 December 2020 Volume 2020:13 Pages 1477—1486

DOI https://doi.org/10.2147/IJGM.S288732

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Yang Dong,* Dongfei Wang,* Jialan Lv, Zhicheng Pan, Rui Xu, Jie Ding, Xiao Cui, Xudong Xie, Xiaogang Guo

Department of Cardiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xiaogang Guo
Department of Cardiology, The First Affiliated Hospital of Zhejiang University School of Medicine, No. 79 Qing Chun Road, Hangzhou 310006, People’s Republic of China
Tel + 86-13867441856
Email gxg22222@zju.edu.cn

Purpose: We aimed to study the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) risk model’s prognostic value and relationship with left ventricular remodeling in dilated cardiomyopathy.
Patients and Methods: Dilated cardiomyopathy patients were prospectively recruited and underwent clinical assessments. MAGGIC risk score was calculated. Patients were followed up for adverse events and echocardiography. Primary endpoints were all-cause mortality and first rehospitalization due to heart failure. Secondary endpoint was left ventricular remodeling defined as a decline in left ventricular ejection fraction > 10% or an increase in left ventricular end-diastolic diameter > 10%. Survival status was examined using Cox regression analysis. The model’s ability to discriminate adverse events and left ventricular remodeling was calculated using a receiver operating characteristics curve.
Results: In total, 114 patients were included (median follow-up time = 31 months). The risk score was independently related to adverse events (2-year all-cause mortality: hazard ratio [HR] = 1.122; 95% confidence interval [CI], 1.043– 1.208; 1-year first rehospitalization due to heart failure: HR = 1.094; 95% CI, 1.032– 1.158; 2-year first rehospitalization due to heart failure: HR = 1.088; 95% CI, 1.033– 1.147, all P < 0.05). One-year change in left ventricular end-diastolic diameter was correlated with the risk score (r = 0.305, P = 0.002). The model demonstrated modest ability in discriminating adverse events and left ventricular remodeling (all areas under the curve were 0.6– 0.7).
Conclusion: The MAGGIC risk score was related to adverse events and left ventricular remodeling in dilated cardiomyopathy.

Keywords: dilated cardiomyopathy, left ventricular remodeling, prognosis, risk model

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]