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Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation

Authors Yang M, Jing L, Wang J, Yu Y, Cao L, Zhang L, Zhou X, Sun Z

Received 5 July 2016

Accepted for publication 10 October 2016

Published 22 November 2016 Volume 2016:11 Pages 6217—6228

DOI https://doi.org/10.2147/IJN.S116492

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Lei Yang


Man Yang,1,2 Li Jing,1,2 Ji Wang,1,2 Yang Yu,1,2 Lige Cao,1,2 Lianshuang Zhang,1,2 Xianqing Zhou,1,2 Zhiwei Sun1,2

1School of Public Health, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China

Abstract: Silica nanoparticles (SiNPs) are amongst the most commonly used materials in the field of nanomedicine and, therefore, their influence on organisms has drawn increasing attention in recent years. Most reports have focused on the single tissue reactions induced by SiNPs. Herein, the reaction of primary organs to SiNPs following intratracheal instillation in mice was analyzed by histopathology and ultrastructure observation. Following elucidation of the role of macrophages in local and systemic inflammation, the underlying mechanisms were explored using a macrophage cell line in vitro. The results suggest that macrophages swallow the SiNPs and secrete inflammatory factors by activating the NLRP3 inflammasome, thus participating in local and systemic inflammation.

Keywords: silica nanoparticles, inflammation, macrophages, organs, NLRP3 inflammasome

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