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Lung cancer in women

Authors Barrera R, Morales Fuentes J

Received 24 August 2012

Accepted for publication 19 October 2012

Published 17 December 2012 Volume 2012:3 Pages 79—89

DOI https://doi.org/10.2147/LCTT.S37319

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Raúl Barrera-Rodriguez,1 Jorge Morales-Fuentes2

1Biochemistry and Environmental Medicine Laboratory, National Institute of Respiratory Disease, 2Lung Cancer Medical Service, National Institute of Respiratory Disease, Tlalpan, Mexico City, Distrito Federal, Mexico
Both authors contributed equally to this work

Abstract: Recent biological advances in tumor research provide clear evidence that lung cancer in females is different from that in males. These differences appear to have a direct impact on the clinical presentation, histology, and outcomes of lung cancer. Women are more likely to present with lung adenocarcinoma, tend to receive a diagnosis at an earlier age, and are more likely to be diagnosed with localized disease. Women may also be more predisposed to molecular aberrations resulting from the carcinogenic effects of tobacco, but do not appear to be more susceptible than men to developing lung cancer. The gender differences found in female lung cancer make it mandatory that gender stratification is used in clinical trials in order to improve the survival rates of patients with lung cancer.

Keywords: lung cancer, adenocarcinoma, women, genetic susceptibility, genetic differences, tobacco

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