Low Trend for VZV-Associated Disease Patients to Visit Neurologists

Introduction

Herpes zoster (HZ) is caused by the reactivation of latent varicella zoster virus (VZV) in the sensory ganglia, such as cranial nerve ganglia and dorsal root ganglia. Although it presents as a painful vesicular rash, HZ is not just a skin disease. HZ episodes can lead to various complications and sequelae, including, neurological disorders such as limb paralysis, cerebrovascular disorders, cardiovascular disease, and serious scarring.¹ Pain is the most common complication, with many cases of acute HZ followed by severe zoster-associated pain (ZAP). This pain may persist for months or even years after the HZ rash heals, which is known as postherpetic neuralgia (PHN). PHN is a type of neuropathic pain caused by damage to the axons and myelin by the VZV.^2,3 This condition, along with acute ZAP, imposes a significant economic burden on the healthcare system,^4,5 which implies there are currently no effective and safe treatments for PHN.⁶ VZV infection is a complex medical condition that requires expertise from multiple specialties, including infectious diseases, immunology, dermatology, pain management, and neurology. Although available guidelines suggest effective agents based on current evidence, they do not provide a specific algorithm for management. This leaves the choice of agents and timing of evaluation to the physician’s discretion.^7–9 A survey of internists and family practitioners found the median number of yearly patient visits for HZ and PHN was two and four, respectively.¹⁰ Unfortunately, only one-quarter of physician respondents referred patients with HZ, and two-thirds referred patients with PHN to a subspecialist. Approximately 3% and just over 20% of respondents reported referring over 10% of their patients with HZ or PHN, respectively, to a subspecialist.¹⁰ This highlights the need for improved treatment methods,⁶ as HZ and PHN continue to be prevalent.¹¹ HZ and ZAP are VZV-infectious peripheral neuropathies or VZV-induced nerve injuries,¹² that require attention from neurologists and researchers as an area of unmet clinical need and as an archetype of neuropathic pain.¹³ This study aimed to assess the frequency of HZ, ZAP, and PHN patients visiting neurologists rather than other specialists.

Materials and Methods

Study Design and Patients

This study is based on EHR, without the direct involvement of patients, and without obtaining informed consent from patients prior to the study. The participants’ data are anonymous, and these changes do not distort the scholarly meaning. This study was approved by the Ethics Review Board of Affiliated Tenth People’s Hospital of Tongji University (SHSY-IEC-4.1/18-203). All procedures involving human participants were performed by the ethical standards of the institutional and national research committee and the 1964 Helsinki Declaration, its later amendments, or comparable ethical standards.

This study was performed with the collaboration of clinics from the following three hospitals in East China: Affiliated Tenth People’s Hospital of Tongji University in Shanghai; Taicang First People’s Hospital in Jiangsu, and Bengbu Second People’s Hospital in Anhui. Randomly select three hospitals from different provinces in Eastern China for research, which represent the characteristics of outpatient diseases in general hospitals in the Yangtze River Basin of Eastern China.

Data Collection

The data were retrieved from electronic health records (EHRs) using the hospital information system for patients with HZ, ZAP, or PHN who were received at one of three general hospitals between January 2017 and June 2022.

Persons with diagnostic codes for HZ (International Classification of Diseases (ICD),¹⁴ Ninth Revision, Clinical Modification codes starting with 053, and Tenth Revision, Clinical Modification codes starting with B02) were categorized as cases with episode start dates based on their earliest recorded diagnosis. Episodes of ZAP were identified using pain medication prescription. PHN was defined by a diagnostic HZ code (B02 or G53.0) or a pain medication prescription during the quarter of the HZ episode or the following quarter. Using ICD diagnostic codes to diagnose zoster was both highly selective (positive predictive value 93%) and sensitive (97.5%).¹⁵ Episodes, where individuals were under 20 years of age at the time of diagnosis, were excluded to avoid misclassification of varicella cases as HZ.

Follow-up data for this set of patients were available up to June 2022, covering 1.0−5.5 years. The EHR was a medical record for patients with HZ, ZAP, or PHN who had received the total activities and services of the hospital and medical specialists within a maximum period of 5.5 years.

Data Analyses

Only fields for patient demographics, medical visits, and diagnoses were retrieved. Two steps of data manipulation and analysis were then performed using SPSS 19.0 and SPSS Modeler 18.0 (IBM Corp., Armonk, NY, USA).

Descriptive statistics (eg, means and proportions) were used to present the patient characteristics of the study population as well as HZ-specific information. The relevant medical specialties considered in our study were as follows: dermatology, internal medicine, geriatrics, neurology, pain management, surgery, ophthalmology, otorhinolaryngology, rehabilitation medicine, Chinese traditional medicine, and other specialties (such as gynecology, oncology, and psychiatry).

We utilized association rule mining (ARM) to detect the selection preference of specialists for individual patients during their entire visit and to analyze the external reason for PHN development and the role of neurologists. ARM is used in many fields of study, including not only market research but also medicine and epidemiology. For example, ARM has been applied in areas such as the prediction of acute myocardial infarction,¹⁶ studies of ADHD comorbidity,¹⁷ and cancer prevention factors.¹⁸ The data were formatted as the “shopping basket”, a single outpatient medical insurance number was analyzed to observe the different EHR and medical specialists’ “co-occurrence” situation, analyzing 50% of the frequent items and association rules of the data. To avoid redundant rules, a support threshold was established as 1%, and confidence thresholds were established as 50%.

Except where stated otherwise, the data were presented as the mean ± standard deviation (SD) or % values. Statistical analysis was made by the Kruskal–Wallis H-test and the one-way ANOVA test. The cut-off for statistical significance was set at p<0.05.

Results

Patients Disposition

In total, 33,633 unique HZ patients were received at the hospital for the first time in January 2017. During follow-up (to June 2022), a total of 111,488 EHRs were invoiced for these patients (Figure 1). The EHR was equally dispersed over the age categories and sexes. Approximately half (51.6%) of the patients were female. Moreover, at the time of first visit to the hospital, 31.5% of the patients were aged between 21 and 49 years, 22.6% were aged between 50 and 59 years, 24.7% were between 60 and 69 years, 12.9% were between 70 and 79 years, and 8.3% were older than 80 years.

Figure 1 Description of inclusion criteria to select the final cohort of patients. Abbreviations: HER, electronic health records; HZ, Herpes zoster; ZAP, zoster-associated pain.

Preferred Specialist at a First Medical Visit

Within the three hospitals, the vast majority (74.77−91.22%) of patients first visit a dermatologist, followed by specialists in pain management (3.05−4.25%), and neurology (0.86−1.47%), except for the rehabilitation specialist in the Affiliated Tenth People’s Hospital of Tongji University (Table 1). The proportion of patients who were received by a specialist during their initial medical visit had significant differences in the different specialties in the same hospital (p <0.05) and significant differences in the same specialty in the three different hospitals (p <0.05).

Table 1 Patients Referral Behaviors

The number of EHRs per patient ranged from 1 to 36, with an average of 3.57 EHRs per patient. Approximately 1% of the patients needed only one EHR, with fewer than 50% of the patients who needed 10 EHRs or more. The majority of EHRs were invoiced by the dermatologist (50.83−88.65%) within the three hospitals, followed by the specialists in pain management (4.63−8.72%), and geriatrics (0.84−1.56%), except for the rehabilitation specialist in the Affiliated Tenth People’s Hospital of Tongji University, respectively. The average number of EHRs was longest for geriatrics (7.84−11.81 times) and shortest for surgery (1.32−1.66 times). The EHR duration per patient ranged from 1 to 356 days, whereas the average EHR duration was 35.72 days per patient. The average EHR duration was the shortest for surgery (5.63−9.25 days) and the longest for pain management (169.98−195.03 days). The proportion of the number of EHRs, the average numbers of EHRs, and the average EHR duration that patients received to specialists had significant differences in the different specialties in the same hospital (p <0.05) and in the same specialty within the three hospitals (p <0.05), respectively (Table 1).

Frequency of Referral Between Different Sub Specialties

A total of 77,855 (69.83%) observations were omitted due to the EHR of only one specialist visit, leaving 33,633 observations for ARM analysis.

After executing the association model, 210 association rules, including 70 rules whose confidence degree is greater than 50%, were obtained. Due to a large number of association rules, it is difficult to elaborate on all the rules. Combined with the purpose of this study, we used only selected meaningful association rules of dermatology and neurology.

When the consequent was dermatology, the ARM was applied and four rules were identified and passed the thresholds of 1% and 50% for the support and confidence parameters, respectively. For the Affiliated Tenth People’s Hospital of Tongji University, the strongest support parameter (9.3%) was between dermatology and ophthalmology, or neurology; the strongest confidence parameter (100.00%) was between dermatology and otorhinolaryngology, or rehabilitation with the highest lift of 1.31; the remainder indicated low associations between dermatology and other specialties. The lift value was 1.07 to 1.31, which implied that there was a weak positive association. The resulting association rules in the other two hospitals are shown in Table 2.

Table 2 Top 4 Results of Association Rule Mining of Referral Behaviors

Analysis of Meaningful Association Rules of Neurology

Although a few patients (42−283) initially visited the neurologist in the three hospitals, only a small number received treatment. The number of EHRs was 102−704; the average number of EHRs was only 1.42−2.49; and the average duration of an EHR was only 11−15 days per patient. The majority of patients (348/704− 88/193−64/102) were referred by other specialists to a neurologist for ZAP in the three hospitals, followed by patient referrals for Ramsay Hunt syndrome (152/704−62/193−26/102) or other disorders (5/704−3/193− 1/102). The proportion of patients referred to a neurologist for ZAP or Ramsay Hunt syndrome varied significantly across different specialties within the same hospital (p<0.05) and even within the same departments within the three hospitals (p<0.05), respectively (Table 3). Additionally, some patients were referred to other specialists after they consulted with a neurologist (Table 3). The proportion of patients referred to other specialists after seeing a neurologist also varied significantly across different specialties within the same hospital (p<0.05) and the same departments in the three hospitals (p<0.05), respectively (Table 3).

Table 3 Patients Referral Behaviors in Neurology Specialists

In the field of neurology, four rules were established and met the required thresholds of 1% and 50% for support and confidence parameters, respectively. Upon analyzing data from the Affiliated Tenth People’s Hospital of Tongji University, it was found that the strongest support parameter (1.6%) and confidence parameter (66.67%) existed between neurology and dermatology, ophthalmology, or traditional Chinese medicine (TCM), with the highest lift of 28.10. This suggests a strong positive association between neurology and dermatology, ophthalmology, or TCM. The resulting association rules in the other two hospitals are shown in Table 2.

Discussion

Although the HZ lesion might influence the patient’s choice bias, our study found that the majority of patients first visited a dermatologist within one of the three hospitals. Following the dermatologist, patients typically visited a pain management specialist. The only exception was the Affiliated Tenth People’s Hospital of Tongji University, where a significant proportion of patients visited rehabilitation experts as their second choice. The Department of Rehabilitation Medicine at the Affiliated Tenth People’s Hospital of Tongji University has primarily focused on providing neuroprotective treatment for ZAP and PHN. As a result, the majority of outpatients received by the department are those with ZAP or PHN, accounting for more than 60% of their total patient population. Including rehabilitation EHRs in this study may lead to a decrease in the proportion of patients visiting dermatologists. Even with this factor, over 70% of patients sought treatment from a dermatologist at the Affiliated Tenth People’s Hospital of Tongji University. Additionally, there were significant differences in the proportion of patients who saw a specialist during their initial medical visit across different specialties within the same hospital (p<0.05). As the three hospitals are not primary healthcare units, a portion of the diagnosed subjects at the time of their initial medical visit in these hospitals may not start onset patients. In cases where shingles are present on the skin, it seems to be the right choice to visit a dermatologist. VZV is a skin-tropic virus.¹⁹ HZ is caused by reactivated-VZV, the virulent progeny virus spreads orthodromically from the ganglion, via the sensory nerve root, to the innervated target tissue (skin, cornea, auditory canal, etc.). During the acute eruptive phase of herpes zoster (HZ), painful vesicles develop in a single dermatome and appear on the skin. These vesicles are typically umbilicated and multiple. The distribution of HZ is usually along the innervating area of one ganglion, although adjacent dermatomes may also be affected.^20,21 HZ is generally self-limiting in immunocompetent patients without risk factors for complications,²² and the acute eruptive phase typically lasts for 2–4 weeks.²⁰ Although dermatology is the first department to see a doctor for the first time with HZ,²³ the time to control virus outbreaks and deal with vesicles is usually limited to one month.²⁰

Despite its outward appearance, the hallmark of HZ in adulthood is pain. More than 95% of patients over the age of 50 experience acute ZAP.²⁴ Additionally, 60–70% of patients continue to experience persistent pain one month after disease onset, and 40% of patients consider their pain to be severe.²⁴ Except for the dermatologist, the second was a pain management specialist within the three hospitals in this study. This aligns with existing guidelines, which were updated in 2020 to provide comprehensive information on pain management and treatment options for both residents and board-certified specialists.²² In cases of persistent intolerable pain, it is advisable to refer patients to a pain specialist.²² Acute ZAP is caused by the spread of the virus along the axon and the migration of immune cells. This leads to subsequent inflammation and damage to sensory nerves and endings.^25–27 The interdisciplinary European consensus-based guidelines on the management of HZ have cautioned that neuroinflammation is partly responsible for painful sensations.²⁸

In the acute phase, it is important to manage neuritic pain. One method proposed in this guideline is to actively intervene in pain management while using antiviral drugs during a rash.^22,29 Unlike PHN, acute ZAP should preferentially be treated with systemic analgesics, initially including non-steroidal anti-inflammatory drugs (NSAIDs) and opioids.²² However, these therapies may not completely alleviate acute ZAP.^29,30 It is worth noting that the incidence and severity of PHN tend to be higher in patients over the age of 50.^31–33 Approximately 20% of patients over the age of 60 years experienced disease complications that persist for more than one year.³⁴ Pain specialists at this stage may employ an analgesic strategy that involves selecting from multiple agents with complementary mechanisms of action, such as gabapentin, pregabalin, tricyclic antidepressants, opioids, and nerve blocks with steroids and local anesthetics, which have demonstrated analgesic activity.³⁵ The latest guidelines emphasize the use of local treatment options, including capsaicin 8% patches and lidocaine 5% medicated plaster.²² According to the 2017 update of a Cochrane review, capsaicin has been found to alleviate pain in all studies.³⁶ The temporary relief of pain is believed to be caused by the deactivation of heat-sensitive epidermal nociceptors that express the Transient Receptor Potential Vanilloid 1 (TRPV1).³⁷ Skin biopsies conducted after prolonged or high-concentration application of capsaicin have shown a significant reduction in intra-epidermal nerve fiber density.^38,39 Recent studies suggest that capsaicin-induced Ca²⁺/calpain-mediated ablation of axonal terminals is required for long-lasting analgesia in a mouse model of neuropathic pain.^40,41 However, this is not an optimal choice for the VZV-damaged nerves. Other neuromodulation treatments, such as pulsed radiofrequency and spinal cord electrical stimulation, may also provide pain relief.¹² The existence of multiple methods implies that the efficacy of analgesic therapy is limited.^12,35 The current analgesic strategy for PHN often falls short, with less than half of patients achieving adequate 50% pain relief.¹³

Management of HZ is not limited to dermatologists and pain management specialists; but also falls under the purview of neurologists. Guidelines suggest providing sufficient pain medication for the typically severe neuralgiform pain and referring patients with specialized conditions to both a neurologist and a specialist.²² The study found that the number of visits to a neurologist for ZAP and PHN within the three hospitals was only 1.42−2.49, with an average EHR duration of 11−15 days per patient. This suggests that only a small number of patients directly visited neurologists. Approximately 50% of the HZ patients visited with neurologists more than one HER, while only 10% (7879 patients) of the patients experienced 10 or more EHRs. The study found that around 80% of patients diagnosed with ZAP reported inadequate pain treatment, suggesting that our neurologist did not effectively intervene in the treatment of ZAP and PHN. Additionally, the results of the ARM analysis revealed a weaker correlation between the referral behaviors of dermatologists and neurologists. While there was a strong positive association among neurologists and dermatologists, ophthalmologists, or TCM doctors, the majority of patients received by other specialists referred to neurologists were for Ramsay Hunt syndrome, followed by ZAP or other disorders. Other studies have shown that most (>60%) of patients with PHN were referred for specialty care, with 30% of them being referred to neurologists.¹⁰ The patterns of medication use were similar across all specialties.¹⁰ Approximately 40% of specialties prescribed narcotics, and >90% prescribed antivirals, to the majority of their patients,¹⁰ which indicated a lack of alternative therapies. The most surprising result of this study was the portion of patients who visited neurologists were later transferred to other specialists, suggesting that many neurologists may not fully understand ZAP (Table 3).

VZV is not only a skin-tropic¹⁹ but also a neurotropic virus.⁴² When the virus reactivates, it is assembled in neuronal cell bodies and transported anterogradely through axons to the nerve ending and epidermis.⁴³ ZAP, especially PHN, is a specific type of neuropathy in which the virulence VZV is transmitted from the neuron to the axon endings,⁴⁴ causing axon destruction from the inside out.⁴⁵ As VZV-induced peripheral axonal damage causes ZAP, it raises the question as to why there is no targeted nerve treatment available. The treatment goal for patients with ZAP should not only focus on pain relief; but also on protecting and repairing damaged nerves. However, current guidelines do not address the importance of neuroprotection or promoting nerve repair in these patients. When faced with nerve damage caused by VZV, many neurologists are unsure of how to proceed. Specialists in HZ typically wait for neuropathic pain to develop, then refer patients to pain management specialists, which can make treating nerve injuries more challenging.

Effective pain management is crucial for patients with ZAP and PHN. However, it is not sufficient on its own. In addition to reducing pain, it is important to promote nerve repair and functional recovery. Immediate protection of affected nerves, controlling the inflammatory reaction of nerve axons, and minimizing nerve damage caused by VZV are all necessary. The attending physicians who have initial contact with the patient play a critical role in the early management of HZ and the prevention of PHN. Unfortunately, attending physicians and dermatologists have not fully grasped the importance of early anti-neuroinflammation and neuroprotection in managing ZAP and reducing the likelihood of PHN.⁴⁶ While ZAP and PHN may require few qualitative and localization diagnoses, effective treatment by neurologists is necessary. Although some patients recognize ZAP as a neuropathic pain and seek out a neurologist, the majority of neurologists do not fully understand this neuropathy. The Department of Rehabilitation Medicine of Affiliated Tenth People’s Hospital of Tongji University has seen a significant influx of patients, highlighting the growing need for effective treatment options.

To address the challenges of ZAP and PHN, it is crucial to adopt mechanism-based approaches. Recent research has suggested a link between ZAP and increased levels of oxygen free radicals and homocysteine (Hcy), as well as reduced levels of vitamins C and D. Firstly, low antioxidant levels may be associated with uncontrolled VZV reactivation, acute nerve damage, and PHN.^47–49 Antioxidant therapy may help in preventing both ZAP and PHN.⁴⁷ Secondly, studies have indicated a high prevalence of Vitamin C deficiency in patients with HZ and PHN, and Vitamin C deficiency independently predicts the development of HZ and PHN.^50–53 Vitamin C has been found to enhance the synthesis of beta-endorphin and endomorphin,^54–56 both of which have well-known analgesic effects, particularly for neuropathic pain.^56,57 Interestingly, at physiological levels, extracellular vitamin C can protect neurons from glutamate excitotoxicity induced by the activation of NMDA receptors.⁵⁸ Ascorbate present within cells directly prevents excessive nerve stimulation caused by glutamate by scavenging ROS,⁵⁹ decreasing cell membrane levels of the NMDA receptor, and inhibiting glutamate uptake by decreasing cell surface levels of the neuronal glutamate transporter.⁶⁰ Furthermore, high-dose Vitamin C has been found to effectively decrease spontaneous pain in PHN.^51,61–64 Thirdly, Vitamin D, has immunotropic properties that could contribute to the development of immune-related diseases such as VZV reactivation.^65–67 Insufficient levels of Vitamin D are associated with PHN.^47,68,69 Vitamin D is essential for the growth, survival, and proliferation of neurons, making it a potential therapeutic option for various neurodegenerative diseases.^70–72 In patients with HZ, Vitamin D supplementation may reduce the likelihood of subsequent PHN, indicating that it could have a protective effect against severe neuroinflammation^47,73,74 Lastly, in their study, Oskay et al discovered that there is a significant positive correlation between the levels of Hcy in severe HZ rashes and the development of PHN.⁴⁷ The increased Hcy levels in HZ may indicate a deficiency of Vitamins B₆, B₁₂, and folate, along with elevated inflammatory markers and oxidative stress.^47,75,76 Neurotropic B vitamins (thiamine, pyridoxine, and cobalamin) play a crucial role in axonal transport, neuron excitability, and neurotransmitter synthesis.^77–80 As modulators, they regulate several inflammatory and neural mediators involved in nociceptive and neuropathic pain through various mechanisms. These mechanisms include targeting the activation of the descending pain modulatory system, specific intracellular pathways, anti-inflammatory, antioxidative, antinociceptive, antiallodynic, anti-hyperalgesic, and nerve regenerative effects.⁸¹ Therefore, understanding the mechanisms underlying the neuroprotective effect of Vitamins B, C, and D can be significant in the treatment of ZAP and PHN.

VZV-induced damage of afferent fibers and endings plays an important role in the pathogenesis of ZAP. It is possible that the involvement or damage to the structure and function of multiple types of afferent nerves and channels in the periphery, rather than just one type of fibers.^44,82 The tips of axons are often far away from the cell soma. Recent studies have shown that axonal mRNA transport and localized translation play important roles in regulating these distant outposts of the cell, allowing them to quickly respond to external factors and maintain axonal homeostasis.⁸³ Localized protein synthesis provides spatiotemporal precision for injury responses and growth decisions at remote positions in nerve axons.⁸⁴ Approximately 83.3% of ZAP is localized, which suggests that topical treatment could be a viable option.⁸⁵ The neurotropic B vitamins are essential for maintaining a healthy nervous system.⁸⁶ Cobalamin, an endogenous neuroprotectant and neurotrophic agent, targets protein synthesis in the distal axonal cytoskeleton⁸⁷ and scavenges superoxide⁸⁸ making it a beneficial treatment for neuropathic pain.⁸⁹ According to several clinical studies, the injection of methylcobalamin locally has shown promising results in treating ZAP and PHN, with an overall effectiveness rate of over 80%.^90–95 Additionally, locally injected thiamine has been found to have a significant antipruritic effect.⁹⁶ These findings suggest that a more targeted approach, focused on protecting the affected nerve, promoting nerve repair, and nourishing the damaged nerve, may be more effective than simply providing analgesia for ZAP and PHN.

The accounting of the public health burden of HZ is incomplete, and changes in the age-specific incidence of HZ further exacerbate knowledge gaps.⁹⁷ As up to one-third of the population may develop HZ from VZV reactivation and suffer from PHN,⁹⁸ it is crucial to strengthen both basic and clinical research. However, our understanding of VZV neuropathy is remarkably poor, particularly in terms of patient visits that lack the involvement of neurologists.⁹⁸

Although 2 vaccines for HZ are currently recommended, the popularization of vaccination still needs time. Neurologists need to be made aware of ZAP and PHN; and urged to give VZV-induced nerve injury the attention it deserves. As medical knowledge and research continue to evolve, it is crucial for medical education to stay up-to-date. As neurologists, we have a responsibility to fully understand this disease and provide patients with timely and effective treatment. The possibility of promoting neural repair strategies based on VZV-induced axonal damage mechanisms is an exciting prospect.

Strengths and Limitations

This study’s strength lies in its unbiased reporting of results, which were based solely on the HER of three hospitals without any influence from the author. The study’s analysis of patients’ visit preferences confirmed the inadequacy of neurologists in treating ZAP. However, the data derived from EHR for the detection of incident HZ and ZAP has limitations. The hospital information system’s EHR data often lacked detailed information on extensive patient characteristics. The study is limited in its ability to examine the potential differences in patient characteristics and treatment practices across hospitals. However, the data from all three hospitals indicates a weak correlation between dermatological and neurological consultations for ZAP or PHN, suggesting these had a certain representation. Additionally, the accuracy of the ICD-9/10-based HZ diagnostic codes used in the study may be limited in their ability to accurately identify cases of HZ. The diagnostic codes commonly used by TCM doctors may not be specific enough to accurately identify cases of HZ, ZAP, and PHN, which could result in slightly lower referral proportions.

Conclusion

Our analysis of association rules revealed that patients with ZAP and PHN tended to have higher rates of visits to dermatology and pain management specialists, as opposed to neurologists. Furthermore, there was less correlation between the referral behaviors of dermatologists and neurologists. Effective management of ZAP and PHN requires multidisciplinary knowledge and involvement. However, it is unfortunate that many neurologists do not actively participate in the treatment of VZV-nerve damage. As experts in anti-neuroinflammation and neuroprotection, it is the duty of neurologists to be actively involved in the treatment of these conditions.