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Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients

Authors Tu X, Qiu H, Lin S, He W, Huang G, Zhang X, Wu Y, He J

Received 30 July 2018

Accepted for publication 27 September 2018

Published 2 November 2018 Volume 2018:14 Pages 2947—2954


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Yuping Ning

Xinjie Tu,* Huihua Qiu,* Shasha Lin, Weilei He, Guiqian Huang, Xingru Zhang, Yuemin Wu, Jincai He

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

*These authors contributed equally to this work

Purpose: Population-based studies have revealed a high prevalence of cognitive impairment after stroke. We aimed to determine the impact of serum magnesium (Mg2+) levels on the occurrence of poststroke cognitive impairment (PSCI).
Patients and methods: Acute ischemic stroke patients (n = 327) were enrolled in our study and serum Mg2+ levels were assessed on admission. The cognitive performance of each patient was evaluated using the Mini–Mental State Examination (MMSE) at a 1-month follow-up visit.
Results: One hundred five (32.1%) patients were diagnosed with PSCI at 1-month poststroke. The serum Mg2+ levels in both the PSCI group and the non-PSCI group were significantly lower than those in normal control group (P<0.001). In addition, the PSCI group had lower levels of serum Mg2+ compared to the non-PSCI group (P=0.003). In the binary logistic regression analysis, a serum Mg2+ level of ≤0.82 mmol/L was significantly associated with an increased risk of developing PSCI by the 1-month follow-up (OR 2.236, 95% CI 1.232–4.058, P=0.008), as was age (OR 1.043, 95% CI 1.014–1.073, P=0.003).
Conclusion: Our results demonstrate the existence of a significant association between low levels of serum Mg2+ and the occurrence of PSCI 1-month poststroke, and these results suggest that low levels of serum Mg2+ on admission may serve as a risk factor for developing PSCI by 1-month poststroke.

Keywords: cognition, magnesium, stroke, risk factor

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