Low levels of plasma endothelin-1 in patients with retinitis pigmentosa

Hiroshi Ohguro¹, Yukihiko Mashima², Mitsuru Nakazawa³

¹Department of Ophthalmology, Sapporo Medical University School of Medicine, ²Department of Ophthalmology, Keio University School of Medicine, ³Department of Ophthalmology, Hirosaki University School of Medicine, Japan

Purpose: The aim of this study was to elucidate the role of endothelin-1 (ET-1) in the pathophysiology of retinitis pigmentosa (RP).

Methods: Plasma ET-1 levels and ophthalmic features in 50 RP patients were compared with those in 20 healthy-eye control subjects. Plasma ET-1 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit.

Results: Mean plasma ET-1 levels of RP patients (1.88 ± 0.56 pg/mL) were significantly lower than those of control subjects (2.30 ± 0.30 pg/mL, Mann-Whitney’s U test; P < 0.01). However, ET-1 concentrations varied markedly in each patient. Among RP patients, a significant correlation of ET-1 concentrations was not observed in terms of its hereditary forms or other clinical factors.

Conclusion: ET-1 may be important in the pathogenesis of RP, and measurement of its plasma concentrations may also contribute to additional insights into the retinal hemodynamics of RP.
Keywords: endothelin-1, retinitis pigmentosa, retinal hemodynamics

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