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Low-dose aripiprazole for refractory burning mouth syndrome

Authors Umezaki Y, Takenoshita M, Toyofuku A

Received 14 August 2015

Accepted for publication 19 February 2016

Published 19 May 2016 Volume 2016:12 Pages 1229—1231

DOI https://doi.org/10.2147/NDT.S94426

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang


Yojiro Umezaki,1 Miho Takenoshita,2 Akira Toyofuku2

1Psychosomatic Dentistry Clinic, Dental Hospital, 2Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

Abstract: We report a case of refractory burning mouth syndrome (BMS) ameliorated with low dose of aripiprazole. The patient was a 66-year-old female who had suffered from chronic burning pain in her tongue for 13 months. No abnormality associated with the burning sensation was detected in the laboratory tests and the oral findings. Considering the clinical feature and the history together, we diagnosed the burning sensation as BMS. The BMS pain was decreased by aripiprazole (powder) 1.0 mg/d, though no other antidepressants had satisfying pain relief. It could be supposed that the efficacy of aripiprazole is caused by dopamine stabilization in this case, and BMS might have a subtype that is reactive to aripiprazole. Further studies are needed to confirm the efficacy of aripiprazole for BMS.

Keywords: burning mouth syndrome, low-dose aripiprazole, chronic pain

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