Back to Journals » International Journal of General Medicine » Volume 2

Long-term radiotherapy related complications in children with head and neck cancer: Another era for pediatric oncologic pathology

Authors Eleftheriadis N, Papalouca D, Eleftheriadis D, Hatzitolios A, Ioannidou-Marathiotou I, Pistevou-Gompaki K

Published 26 March 2009 Volume 2009:2 Pages 63—66

DOI https://doi.org/10.2147/IJGM.S4878

Review by Single-blind

Peer reviewer comments 3


Nikolaos Eleftheriadis2, Christos Papaloukas1, Damianos Eleftheriadis1, Apostolos Hatzitolios2, Ioulia Ioannidou-Marathiotou3, Kiki Pistevou-Gompaki1

1Department of Radiation, Oncology, AHEPA University Hospital; 2A’Propedeutic Department of Internal Medicine, AHEPA University Hospital; 3Department of Orthodontics, School of Dentistry, Aristotle’s University of Thessaloniki, Greece

Abstract: Long-term radiotherapy-related complications in children with head and neck cancer have been frequently reported, especially facial growth disorders and dental abnormalities. We report on two male children (8 and 14 years old) with head and neck cancer, who were successfully treated with chemoradiotherapy and presented with growth deficiency of middle face and mandible hypoplasia, eight years and one year later, respectively. These severe growth complications attributed to chemoradiotherapy, while the patients survived primary malignancy. Patient age at irradiation was significantly correlated with the severity of disorders. We consider late sequelae in children with head and neck cancer due to chemoradiotherapy another era for pediatric oncologic pathology for prevention, if possible, or to manage them efficiently.

Keywords: radiotherapy, head and neck cancer, growth disorders

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]