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Long-term management of Alport syndrome in pediatric patients

Authors Kashtan CE

Received 12 March 2013

Accepted for publication 24 April 2013

Published 4 June 2013 Volume 2013:4 Pages 41—45

DOI https://doi.org/10.2147/PHMT.S35667

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6


Clifford E Kashtan

Department of Pediatrics, Division of Nephrology, University of Minnesota Medical School, Minneapolis, MN, USA

Abstract: Alport syndrome, an important inherited cause of end-stage renal disease, has long been considered an untreatable disorder. That view is changing as a result of treatment studies in experimental animals and human populations. This review describes current management of Alport kidney disease, which is based on early diagnosis and institution of therapy with antagonists of the renin-angiotensin-aldosterone system.

Keywords: Alport syndrome, glomerular basement membrane, type IV collagen, familial hematuria

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