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Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women

Authors Gangadhara S, Bertelli G

Published 2 April 2009 Volume 2009:5 Pages 291—300


Review by Single-blind

Peer reviewer comments 2

Sharath Gangadhara, Gianfilippo Bertelli

South West Wales Cancer Institute, Singleton Hospital, Swansea, UK

Abstract: For more than 20 years, tamoxifen has been the gold standard for the adjuvant treatment of postmenopausal women with hormone-responsive early breast cancer. However, recent randomized trials have shown efficacy and tolerability benefits with the third-generation aromatase inhibitor anastrozole, resulting in an increased use of this agent in the adjuvant setting. Data on anastrozole’s long-term efficacy and tolerability are therefore of interest in clinical practice and will be reviewed here, especially in the light of the 100-month analysis of the ATAC (Anastrozole, Tamoxifen Alone or in Combination) trial.

Keywords: anastrozole, aromatase inhibitors, breast cancer, adjuvant therapy


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