Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study

Authors Saito H, Nomura K, Abe S, Motegi T, Ishii T, Hattori K, Kusunoki Y, Gemma A, Kida K

Received 22 April 2015

Accepted for publication 29 June 2015

Published 29 October 2015 Volume 2015:10(1) Pages 2311—2318

DOI https://doi.org/10.2147/COPD.S87135

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

Hitoshi Saito,1,2 Koichiro Nomura,1,2,† Shinji Abe,1,2 Takashi Motegi,2,3 Takeo Ishii,2,3 Kumiko Hattori,2,3 Yuji Kusunoki,2,3 Akihiko Gemma,2 Kozui Kida2,3

1Department of Respiratory Medicine, Tokyo Metropolitan Hiroo Hospital, 2Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, 3Respiratory Care Clinic, Nippon Medical School

Koichiro Nomura passed away on July 30, 2014


Objective: Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD.
Participants: Subjects included 87 patients either with COPD or at risk of COPD (symptomatic) who underwent gastrectomy between December 2003 and October 2013 (group A), and 174 patients either with COPD or at risk of COPD, matched by age (±5 years), sex, and forced expiratory volume in 1 second (FEV1) as percentage of predicted (FEV1% predicted) (±5%) (group B).
Methods: All patients underwent routine blood chemistry and pulmonary function tests, arterial blood gas analysis, 6-minute walk test (6MWT), high-resolution chest computed tomography scans, and nutritional assessments.
Results: The mean duration postgastrectomy was 18.3±15.4 years. The mean FEV1 and FEV1% predicted were 2.07±0.76 L and 74.6±24.5%, respectively. Univariate analysis indicated that group A patients had significantly lower body mass index, fat-free mass index, and serum hemoglobin and albumin concentration (all P=0.00), and walked a significantly shorter distance in the 6MWT (P<0.05). Multivariate linear regression analysis for the distance in the 6MWT indicated that increased residual volume (RV) to total lung capacity (TLC) as percentage of predicted (%RV/TLC) alone was an independent and significant predictor of reduced distances in the 6MWT.
Conclusion: We concluded that nutritional insufficiency in patients with COPD (or those at risk of COPD) who previously underwent gastrectomy might lead to hyperinflation and consequently, decreased exercise capacity.

Keywords: chronic obstructive pulmonary disease, nutritional insufficiency, 6-minute walk test

Letter to the Editor has been received and published for this article.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Furutate R, Ishii T, Wakabayashi R, Motegi T, Yamada K, Gemma A, Kida K

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:423-430

Published Date: 8 August 2011

Readers of this article also read:

COPD advances in left ventricular diastolic dysfunction

Kubota Y, Asai K, Murai K, Tsukada YT, Hayashi H, Saito Y, Azuma A, Gemma A, Shimizu W

International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:649-655

Published Date: 29 March 2016

Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy

Amreddy N, Muralidharan R, Babu A, Mehta M, Johnson EV, Zhao YD, Munshi A, Ramesh R

International Journal of Nanomedicine 2015, 10:6773-6788

Published Date: 29 October 2015

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

Kim YH, Choi HY, Lee SH, Lim HS, Miki T, Kang JK, Han KG, Bae KS

Drug Design, Development and Therapy 2015, 9:1735-1742

Published Date: 23 March 2015

Impact of β-blocker selectivity on long-term outcomes in congestive heart failure patients with chronic obstructive pulmonary disease

Kubota Y, Asai K, Furuse E, Nakamura S, Murai K, Tsukada YT, Shimizu W

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:515-523

Published Date: 5 March 2015

Curcumin and 5-Fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia

Balasubramanian S, Girija AR, Nagaoka Y, Iwai S, Suzuki M,
Kizhikkilot V, Yoshida Y, Maekawa T, Nair SD

International Journal of Nanomedicine 2014, 9:437-459

Published Date: 9 January 2014

Alterations with age in peripheral blood lymphocyte subpopulations and cytokine synthesis in beagles

Fujiwara M, Yonezawa T, Arai T, Yamamoto I, Ohtsuka H

Veterinary Medicine: Research and Reports 2012, 3:79-84

Published Date: 27 August 2012

Excessive visceral fat accumulation in advanced chronic obstructive pulmonary disease

Furutate R, Ishii T, Wakabayashi R, Motegi T, Yamada K, Gemma A, Kida K

International Journal of Chronic Obstructive Pulmonary Disease 2011, 6:423-430

Published Date: 8 August 2011