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Long noncoding RNAs in gastric cancer: functions and clinical applications

Authors Wang J, Sun J, Wang J, Song Y, Gao P, Shi J, Chen P, Wang Z

Received 29 August 2015

Accepted for publication 28 November 2015

Published 10 February 2016 Volume 2016:9 Pages 681—697

DOI https://doi.org/10.2147/OTT.S95412

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati

Jiajun Wang,* Jingxu Sun,* Jun Wang, Yongxi Song, Peng Gao, Jinxin Shi, Ping Chen, Zhenning Wang

Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, People’s Republic of China

*These authors contributed equally to this work


Abstract: Over the last two decades, genome-wide studies have revealed that only a small fraction of the human genome encodes proteins; long noncoding RNAs (lncRNAs) account for 98% of the total genome. These RNA molecules, which are >200 nt in length, play important roles in diverse biological processes, including the immune response, stem cell pluripotency, cell proliferation, apoptosis, differentiation, invasion, and metastasis by regulating gene expression at the epigenetic, transcriptional, and posttranscriptional levels. However, the detailed molecular mechanisms underlying lncRNA function are only partially understood. Recent studies showed that many lncRNAs are aberrantly expressed in gastric cancer (GC) tissues, gastric juice, plasma, and cells, and these alterations are linked to the occurrence, progression, and outcome of GC. Here, we review the current knowledge of the biological functions and clinical aspects of lncRNAs in GC.

Keywords: long noncoding RNA, gastric cancer, biomarker, target therapy

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