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Long Noncoding RNAs in Diffuse Large B-Cell Lymphoma: Current Advances and Perspectives

Authors Huang X, Qian W, Ye X

Received 10 March 2020

Accepted for publication 28 April 2020

Published 18 May 2020 Volume 2020:13 Pages 4295—4303

DOI https://doi.org/10.2147/OTT.S253330

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Sanjay Singh


Xianbo Huang,1 Wenbin Qian,2 Xiujin Ye1

1Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China; 2Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People’s Republic of China

Correspondence: Xiujin Ye
Tel +86-571-87235875
Fax +86-571-87235560;
Email yxjsunny@zju.edu.cn

Wenbin Qian
Tel/Fax +86-571-89713674
Email qianwb@zju.edu.cn

Abstract: Diffuse large B-cell lymphoma (DLBCL) is a complex and aggressive malignancy originating from B lymphocytes and characterized by extensive clinical, phenotypic and molecular heterogeneity. Although research conducted over the past decades has substantially improved our understanding of DLBCL, its pathogenesis has not yet been fully elucidated. The development of RNA sequencing technology has allowed the identification of numerous long noncoding RNAs (lncRNAs) that exhibit aberrant expression in DLBCL. These lncRNAs play crucial roles in DLBCL development and pathogenesis and are thus good candidates for use as diagnostic biomarkers or therapeutic targets. In this review, we describe the lncRNAs associated with DLBCL, summarize their characteristics and molecular functions, and discuss their relationships with clinical practice.

Keywords: diffuse large B-cell lymphoma, long noncoding RNA, biomarkers

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