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Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data

Authors Yang P, Xu Z, Chen T, He Z

Received 11 December 2015

Accepted for publication 17 February 2016

Published 26 April 2016 Volume 2016:9 Pages 2465—2478

DOI https://doi.org/10.2147/OTT.S102348

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Professor Min Li


Peng Yang,1,* Zi-Peng Xu,1,* Tao Chen,1 Zhen-Yu He2

1The Second Clinical Medical College of Nanjing Medical University, 2Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People’s Republic of China

*These authors contributed equally to this work

Abstract: Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC.

Keywords: colorectal cancer, lymph node metastasis, long noncoding RNA, microarray, ENST00000430471

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