Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Lobe-based computed tomography assessment of airway diameter, airway or vessel number, and emphysema extent in relation to the clinical outcomes of COPD

Authors Kurashima K, Takaku Y, Hoshi T, Kanauchi T, Nakamoto K, Takayanagi N, Yanagisawa T, Sugita Y, Kawabata Y

Received 28 January 2015

Accepted for publication 1 April 2015

Published 2 June 2015 Volume 2015:10(1) Pages 1027—1033

DOI https://doi.org/10.2147/COPD.S81748

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Kazuyoshi Kurashima,1 Yotaro Takaku,1 Toshiko Hoshi,2 Tetsu Kanauchi,2 Keitaro Nakamoto,1 Noboru Takayanagi,1 Tsutomu Yanagisawa,1 Yutaka Sugita,1 Yoshinori Kawabata3

1Respiratory Medicine, 2Radiology, 3Pathology, Saitama Cardiovascular and Respiratory Center, Saitama, Japan

Objective: The aim of this study was to evaluate the relationship between computed tomography assessed lobe-based lung parameters and the clinical outcomes of patients with chronic obstructive pulmonary disease (COPD), including the frequency of exacerbation and annual change in forced expiratory volume in 1 second (FEV1).
Patients and methods: We studied 65 patients with COPD. We reconstructed computed tomography images to trace the bronchial tree from right B1 to B10 and created 3 cm circle images around the airways exactly perpendicular to the airway axis in the central, middle, and peripheral zones of the bronchi. The number of airways and vessels, airway inner diameter and area of emphysema in the circles were calculated for each segment. Then, we analyzed the relationships between the lobe-based image parameters and the frequency of exacerbation and annual decline in the FEV1. In addition, we assessed the effects of proximal airway lumen-obliterated emphysema (ALOE) on these clinical features.
Results: The airway diameter was not associated with the frequency of exacerbation or annual decline in FEV1. Among the structural parameters, lower lobe emphysema was most associated with the frequency of exacerbation. The reductions in the number of airways and vessels in total lobe were associated with the annual decline in FEV1. The subgroup of patients with ALOE demonstrated lower FEV1 and more frequent exacerbation than those without ALOE.
Conclusion: Lower lobe emphysema predicts frequent COPD exacerbation, whereas the annual decline in FEV1 is associated with the number of airways and vessels in total lobe.

Keywords: chronic obstructive pulmonary disease, computed tomography, acute exacerbation, pulmonary function tests, low attenuation area
 

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

COPD assessment test and severity of airflow limitation in patients with asthma, COPD, and asthma–COPD overlap syndrome

Kurashima K, Takaku Y, Ohta C, Takayanagi N, Yanagisawa T, Sugita Y

International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:479-487

Published Date: 4 March 2016

Changes in the airway lumen and surrounding parenchyma in chronic obstructive pulmonary disease

Kurashima K, Hoshi T, Takaku Y, Kanauchi T, Nakamoto K, Ueda M, Takayanagi N, Colby TV, Sugita Y, Kawabata Y

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:523-532

Published Date: 30 October 2013

Readers of this article also read:

COPD exacerbation frequency and its association with health care resource utilization and costs

Dhamane AD, Moretz C, Zhou Y, Burslem K, Saverno K, Jain G, Renda A, Kaila S

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2609-2618

Published Date: 3 December 2015

Prognostic factors for clinical failure of exacerbations in elderly outpatients with moderate-to-severe COPD

Wilson R, Anzueto A, Miravitlles M, Arvis P, Haverstock D, Trajanovic M, Sethi S

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:985-993

Published Date: 2 June 2015

Analysis of autonomic modulation after an acute session of resistance exercise at different intensities in chronic obstructive pulmonary disease patients

Nicolino J, Ramos D, Leite MR, Rodrigues FM, Silva BS, Tacao GY, Toledo AC, Vanderlei LC, Ramos EM

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:223-229

Published Date: 29 January 2015

Impact of chronic obstructive pulmonary diseases on left ventricular diastolic function in hospitalized elderly patients

Huang YS, Feng YC, Zhang J, Bai L, Huang W, Li M, Sun Y

Clinical Interventions in Aging 2015, 10:81-87

Published Date: 19 December 2014

Quantitative assessment of walking time and postural change in patients with COPD using a new triaxial accelerometer system

Kawagoshi A, Kiyokawa N, Sugawara K, Takahashi H, Sakata S, Miura S, Sawamura S, Satake M, Shioya T

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:397-404

Published Date: 2 September 2013

Decline of arterial cerebral infarction among young women: the Bergen Stroke Study

Halvor Naess, Annette Fromm, Ole Erik Iversen, et al

Vascular Health and Risk Management 2011, 7:81-84

Published Date: 15 February 2011