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LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16

Authors Tang X, Long Y, Xu L, Yan X

Received 8 October 2019

Accepted for publication 11 January 2020

Published 23 March 2020 Volume 2020:12 Pages 2119—2125

DOI https://doi.org/10.2147/CMAR.S233859

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Yong Teng


Xiaoqiong Tang, Yaoying Long, Liuyue Xu, Xinyu Yan

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing City 400016, People’s Republic of China

Correspondence: Xiaoqiong Tang
Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, YuZhong District, Chongqing City 400016, People’s Republic of China
Tel +86 23-89011508
Email cebzpn3@163.com

Introduction: LncRNA mortal obligate RNA transcript (MORT) is downregulated in different types of cancer, indicating its involvement in cancer biology.
Methods: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. The low levels of MORT and miRNA-16 were correlated with poor survival of MCL patients. The expression of MORT and miRNA-16 was positively correlated only in MCL patients.
Results: Overexpression of MORT and miRNA-16 suppressed cell proliferation but promoted cancer cell apoptosis, while miRNA-16 inhibitor reduced the effects of MORT overexpression. Overexpression of MORT led to upregulated expression of miRNA-16, while overexpression of miRNA-16 had no effect on the expression of MORT.
Conclusion: Therefore, MORT may inhibit cancer cell proliferation and promote apoptosis in mantle cell lymphoma by upregulating miRNA-16.

Keywords: mantle cell lymphoma, MORT, miRNA-16, prognosis, cancer cell

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