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Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells

Authors Singh S

Received 14 October 2016

Accepted for publication 30 October 2016

Published 15 March 2018 Volume 2018:13(T-NANO 2014 Abstracts) Pages 11—13

DOI https://doi.org/10.2147/IJN.S124701

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Sanjay Singh

Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India


Abstract: Therapeutic agents aimed at inhibiting a single molecular target have not been successful in cancer therapy, but rather they impart resistance. However, multi-target inhibitors have shown promising results in circumventing the development of resistance and inducing apoptosis in cancer cells/tissues. In this study, we encapsulated doxorubicin and celecoxib in a single liposome at a ratio of 1:10. These dual drug-encapsulated liposomes showed excellent anticancer activity compared to individually encapsulated liposomes. The expression of key proteins such as AKT and COX-2 was suppressed, which suggests that doxorubicin and celecoxib synergistically inhibit multiple key signaling pathways.

Keywords: drug delivery, nanoliposomes, nanomedicines, cancer nanotechnology

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