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Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Authors Sheha D, El-Korashi L, AbdAllah AM, El Begermy MM, Elzoghby DM, Elmahdi A

Received 12 November 2020

Accepted for publication 8 January 2021

Published 4 February 2021 Volume 2021:14 Pages 109—117

DOI https://doi.org/10.2147/JAA.S290813

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Luis Garcia-Marcos


Dina Sheha,1 Lobna El-Korashi,2 Amany M AbdAllah,3 Marwa M El Begermy,4 Doaa M Elzoghby,5 Amira Elmahdi1

1Department of Internal Medicine, Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 3Department of Family Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 4Department of Otorhinolaryngology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 5Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence: Dina Sheha
Faculty of Medicine, Ain Shams University, El-Abbassia Street, Cairo, 11566, Egypt
Tel +20 1001525144
Email DinaSheha@med.asu.edu.eg

Background: Recent data display the possible role of cytokines such as interleukin-10 (IL-10), IL-17 and IL-23 as a link between dyslipidemia and atopy; however, the relationship between dyslipidemia, allergic rhinitis (AR), and the underlying mechanisms involved is unclear.
Purpose: To measure the lipid profile and IL-17A level in AR patients in comparison to healthy controls, and correlate serum lipid level with the severity of symptoms and quality of life (QoL) of AR patients.
Patients and Methods: Peripheral blood samples were collected from AR patients (n=70) and a control group (n=80). Samples were analyzed for serum total IgE by ELISA, serum lipid profile, and IL-17A level by ELISA. Severity of AR symptoms was assessed by visual analogue scale (VAS) score and the rhinoconjunctivitis QoL questionnaire.
Results: Serum lipid profile and level of IL-17A in AR patients were significantly higher in comparison to controls (P < 0.001). Positive correlations were found between total cholesterol (TC) and the severity of AR and QoL. IL-17A was positively correlated with triglyceride (TG) level and low-density lipoprotein cholesterol (LDL-C) (P=0.011, r=0.303; P=0.043, r=0.242, respectively). Additionally, IL-17A was negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (P=0.036, r=− 0.251). IL-17A was positively correlated with both age and VAS score with statistical significance (P=0.033, r=0.225; P=0.011, r=0.302, respectively).
Conclusion: Dyslipidemia might play a potential role in the severity of AR symptoms and impairment of patients’ QoL. Highlighting this association might alert physicians to evaluate the lipid profile in AR patients for timely diagnosis and treatment of dyslipidemia in an attempt to improve disease control and improve QoL.

Keywords: allergic rhinitis, cholesterol, dyslipidemia, IgE, interleukin-17, quality of life

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