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LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis

Authors Liu F, Wen C

Received 31 October 2019

Accepted for publication 4 January 2020

Published 5 February 2020 Volume 2020:12 Pages 855—861

DOI https://doi.org/10.2147/CMAR.S236832

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Chien-Feng Li


Fengjuan Liu, Chuansong Wen

Department of Gynecology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, People’s Republic of China

Correspondence: Chuansong Wen
Department of Gynecology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, No. 4 Xueshi Road, Shangcheng District, Hangzhou, Zhejiang 310006, People’s Republic of China
Tel +86-15867187766
Email chuansong_wen@163.com

Background: Long noncoding RNAs have essential roles in human diseases, including cancer. Our work aims to assess the function and mechanisms of LINC01410 in cervical cancer (CC) development.
Methods: Expression analyses were performed using qRT-PCR. Proliferation was determined through CCK8 and colony formation assays. Cell migration and invasion were determined by Transwell assay. The interactions among LINC01410, miR-2467-3p and VOPP1 were analyzed via luciferase reporter assay.
Results: LINC01410 was upregulated in CC tissues and cell lines. LINC01410 upregulation correlated with poor prognosis. LINC01410 silencing suppressed proliferation, migration and invasion of CC cells. LINC01410 was the sponge for miR-2467. And LINC01410 promoted VOPP1 expression through inhibiting miR-2467.
Conclusion: Our findings demonstrated that LINC01410 contributed to CC progression through regulating miR-2467/VOPP1 axis and suggested that LINC01410/miR-2467/VOPP1 cascade may be a potential therapeutic target.

Keywords: LINC01410, miR-2467-3p, VOPP1, cervical cancer, progression


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