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Lifestyle diseases and cardiovascular risk factors are interrelated to deficiencies of major substrates in ATP synthesis

Authors Ditzel J, Lervang H

Published 17 September 2010 Volume 2010:6 Pages 829—836

DOI https://doi.org/10.2147/VHRM.S13368

Review by Single-blind

Peer reviewer comments 2


Jørn Ditzel, Hans-Henrik Lervang
Department of Endocrinology, Center for Prevention of Struma and Metabolic Diseases, Aalborg University Hospital, Aarhus University, Aalborg, Denmark

Abstract: Recent studies on diabetes and metabolic syndrome indicate a common disturbance of inorganic phosphate (Pi) metabolism. Pi is an important substrate in the formation of adenosine triphosphate (ATP), and many lifestyle diseases and cardiovascular risk factors similarly show deficiencies in either 1 or 2 major components of ATP synthesis. Age, male gender, hypertension, obesity, hypertriglyceridemia, metabolic syndrome, and diabetes mellitus are all associated with hypophosphatemia. In addition, tobacco smoking, hyperchylomicronemia, hypertension, and diabetes may involve defects in tissue oxygen delivery. Hypophosphatemia may lead to a critical decrease in intracellular Pi and to mitochondrial dysfunction, which might be counteracted by the pharmacological use of fructose 1,6-diphosphate.

Keywords: hypophosphatemia, hypoxia, diabetes, metabolic syndrome, hypertension

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