Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis
José-Juan Mondejar,1,4 David Salom,1,3 Salvador Garcia-Delpech,1,2 Manuel Diaz-Llopis1
1Ophthalmology Department, School of Medicine, University of Valencia, 2Ophthalmology Department, Hospital Universitario La Fe, 3Ophthalmology Department, Hospital de Manises, Valencia, 4Ophthalmology Department, Hospital General Universitario de Alicante, Alicante, Spain
Purpose: To measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis.
Methods: A prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measured using an enzyme-linked immunosorbent assay (ELISA). The results obtained were compared with those of a control group.
Results: Serum concentrations of TPO were not significantly different between control individuals and patients with active anterior uveitis. Aqueous humor TPO levels were 54.46±16.24 pg/mL in the eyes of patients with uveitis, and 34.32±11.63 pg/mL in the eyes of controls. The difference between the two groups was significant (Mann–Whitney U-test for independent data, P=0.0008), with uveitis patients exhibiting significantly higher levels of TPO.
Conclusion: The high levels of TPO in the aqueous humors of uveitis patients points toward a cytoprotective role of this factor in inflammatory repair processes and the recovery of tissue homeostasis.
Keywords: TPO, thrombopoietin, aqueous humors, serum, acute anterior uveitis, cytoprotective
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