Letter to the editor regarding "Prognostic role of microRNA-150 in various carcinomas: a meta-analysis"
Min Li,1 Ying Yang2
1Department of Oncology, Changsha Central Hospital, Changsha, Hunan, 2Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
Emerging evidence has shown that aberrant microRNA expression has the potential to be used for predicting survival and treatment response of carcinomas.1–3 Recently, the role of miR-150 was investigated in various types of cancers, but the results were inconsistent and inconclusive.4–7 Therefore, we read with great interest the enlightening work of Wang et al8 published in OncoTargets and Therapy. This study conducted a meta-analysis to evaluate the prognostic significance of miR-150 in various carcinomas by calculating the pooled hazard ratio (HR) of both overall survival (OS) and progression-free survival (PFS) in patients with various types of cancer. The authors concluded that miR-150 expression was not significantly associated with multiple cancers in terms of OS, whereas the high expression of miR-150 was significantly associated with worse progression. It is a very interesting and valuable study. Before accepting their conclusions, we would like to express some concerns in relation to their meta-analysis.
View the original paper by Wang et al.
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