Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

Authors Darwiche K, Zarogoulidis P, Krauss L, Oezkan F, Walter RFH, Werner R, Theegarten D, Sakkas L, Sakkas A, Hohenforst-Schmidt W, Zarogoulidis K, Freitag L

Received 13 September 2013

Accepted for publication 4 October 2013

Published 22 November 2013 Volume 2013:8(1) Pages 4533—4542

DOI https://doi.org/10.2147/IJN.S54418

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Kaid Darwiche,1 Paul Zarogoulidis,1,2 Leslie Krauss,3 Filiz Oezkan,1 Robert Fred Henry Walter,1,4 Robert Werner,4 Dirk Theegarten,4 Leonidas Sakkas,5 Antonios Sakkas,5 Wolfgang Hohenforst-Scmidt,6 Konstantinos Zarogoulidis,1 Lutz Freitag1

1Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany; 2Pulmonary Department, Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3CytoViva, Inc, Auburn, AL, USA; 4Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; 5Pathology Department, G Papanikolaou General Hospital, Thessaloniki, Greece; 6II Medical Department, Coburg Regional Clinic, University of Wuerzburg, Coburg, Germany

Background: There are currently many techniques and devices available for the diagnosis of lung cancer. However, rapid on-site diagnosis is essential for early-stage lung cancer, and in the current work we investigated a new diagnostic illumination nanotechnology.
Methods: Tissue samples were obtained from lymph nodes, cancerous tissue, and abnormal intrapulmonary lesions at our interventional pulmonary suites. The following diagnostic techniques were used to obtain the samples: endobronchial ultrasound bronchoscopy; flexible bronchoscopy; and rigid bronchoscopy. Flexible and rigid forceps were used because several of the patients were intubated using a rigid bronchoscope. In total, 30 tissue specimens from 30 patients were prepared. CytoViva® illumination nanotechnology was subsequently applied to each of the biopsy tissue slides.
Results: A spectral library was created for adenocarcinoma, epidermal growth factor receptor mutation-positive adenocarcinoma, squamous cell carcinoma, usual interstitial pneumonitis, nonspecific interstitial pneumonitis, typical carcinoid tumor, sarcoidosis, idiopathic pulmonary fibrosis, small cell neuroendocrine carcinoma, thymoma, epithelioid and sarcomatoid mesothelioma, cryptogenic organizing pneumonia, malt cell lymphoma, and Wegener's granulomatosis.
Conclusion: The CytoViva software, once it had created a specific spectral library for each entity, was able to identify the same disease again in subsequent paired sets of slides of the same disease. Further evaluation of this technique could make this illumination nanotechnology an efficient rapid on-site diagnostic tool.

Keywords: lung cancer, endobronchial ultrasound, spectral imaging, diagnosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

A retrograde y-stenting of the trachea for treatment of mediastinal fistula in an unusual situation

Hohenforst-Schmidt W, Zarogoulidis P, Steinheimer M, Schneider T, Benhassen N, Rupprecht H, Freitag L

Therapeutics and Clinical Risk Management 2017, 13:655-661

Published Date: 23 May 2017

Second-line afatinib administration in an elderly patient with squamous cell carcinoma

Hohenforst-Schmidt W, Zarogoulidis P, Steinheimer M, Benhassen N, Sardeli C, Stalikas N, Toitou M, Huang H

Therapeutics and Clinical Risk Management 2017, 13:341-343

Published Date: 20 March 2017

Massive chest wall resection and reconstruction for malignant disease

Foroulis CN, Kleontas AD, Tagarakis G, Nana C, Alexiou I, Grosomanidis V, Tossios P, Papadaki E, Kioumis I, Baka S, Zarogoulidis P, Anastasiadis K

OncoTargets and Therapy 2016, 9:2349-2358

Published Date: 19 April 2016

A rare case of anastomosis between the external and internal jugular veins

Karapantzos I, Zarogoulidis P, Charalampidis C, Karapantzou C, Kioumis I, Tsakiridis K, Mpakas A, Sachpekidis N, Organtzis J, Porpodis K, Zarogoulidis K, Pitsiou G, Zissimopoulos A, Kosmidis C, Fouka E, Demetriou T

International Medical Case Reports Journal 2016, 9:73-75

Published Date: 21 March 2016

Single sternal metastasis due to malignant melanoma with unexpected long-term survival: a case report

Gogakos AS, Paliouras D, Asteriou C, Rallis T, Lazopoulos A, Chatzinikolaou F, Zissimopoulos A, Tsavlis D, Tsirgogianni K, Zarogoulidis K, Porpodis K, Tsakiridis K, Pitsiou G, Kioumis I, Karapantzos I, Karapantzou C, Sachpekidis N, Zarogoulidis P, Barbetakis N

OncoTargets and Therapy 2016, 9:321-323

Published Date: 18 January 2016

Video-assisted thoracic surgery reduces early postoperative stress. A single-institutional prospective randomized study

Asteriou C, Lazopoulos A, Rallis T, Gogakos AS, Paliouras D, Tsakiridis K, Zissimopoulos A, Tsavlis D, Porpodis K, Hohenforst-Schmidt W, Kioumis I, Organtzis J, Zarogoulidis K, Zarogoulidis P, Barbetakis N

Therapeutics and Clinical Risk Management 2016, 12:59-65

Published Date: 12 January 2016

Coexistence of squamous cell tracheal papilloma and carcinoma treated with chemotherapy and radiotherapy: a case report

Paliouras D, Gogakos A, Rallis T, Chatzinikolaou F, Asteriou C, Tagarakis G, Organtzis J, Tsakiridis K, Tsavlis D, Zissimopoulos A, Kioumis I, Hohenforst-Schmidt W, Zarogoulidis K, Zarogoulidis P, Barbetakis N

Therapeutics and Clinical Risk Management 2016, 12:1-4

Published Date: 21 December 2015

EGFR-TKIs in adjuvant treatment of lung cancer: to give or not to give?

Milovancev A, Stojsic V, Zaric B, Kovacevic T, Sarcev T, Perin B, Zarogoulidis K, Tsirgogianni K, Freitag L, Darwiche K, Tsavlis D, Zissimopoulos A, Stratakos G, Zarogoulidis P

OncoTargets and Therapy 2015, 8:2915-2921

Published Date: 13 October 2015

Sex differences of continuous positive airway pressure treatment on flow-mediated dilation in patients with obstructive sleep apnea syndrome

Kallianos A, Panoutsopoulos A, Mermigkis C, Kostopoulos K, Papamichail C, Kokkonouzis I, Kostopoulos C, Nikolopoulos I, Papaiwannou A, Lampaki S, Organtzis J, Pitsiou G, Zarogoulidis P, Trakada G

Clinical Interventions in Aging 2015, 10:1361-1367

Published Date: 19 August 2015

Reduction of exercise capacity in sarcoidosis in relation to disease severity

Kallianos A, Zarogoulidis P, Ampatzoglou F, Trakada G, Gialafos E, Pitsiou G, Pataka A, Veletza L, Zarogoulidis K, Hohenforst-Schmidt W, Petridis D, Kioumis I, Rapti A

Patient Preference and Adherence 2015, 9:1179-1188

Published Date: 18 August 2015

Roflumilast, a phosphodiesterase-4 inhibitor, induces phagocytic activity in Greek COPD patients

Porpodis K, Domvri K, Zarogoulidis P, Petridis D, Tsirgogianni K, Papaioannou A, Hatzizisi O, Kioumis I, Liaka A, Kikidaki V, Lampaki S, Organtzis J, Zarogoulidis K

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1123-1128

Published Date: 15 June 2015

Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle – a perspective on a new tool to avoid stent migration of Dumon stents

Hohenforst-Schmidt W, Linsmeier B, Zarogoulidis P,Freitag L, Darwiche K, Browning R, Turner JF, Huang H, Li Q, Vogl T, Zarogoulidis K, Brachmann J, Rittger H

Therapeutics and Clinical Risk Management 2015, 11:837-850

Published Date: 22 May 2015

DDMC-p53 gene therapy with or without cisplatin and microwave ablation

Hohenforst-Schmidt W, Zarogoulidis P, Stopek J, Vogl T, Hübner F, Turner JF, Browning R, Zarogoulidis K, Drevelegas A, Drevelegas K, Darwiche K, Freitag L, Rittger H

OncoTargets and Therapy 2015, 8:1165-1173

Published Date: 20 May 2015

Exhaled volatile organic compounds discriminate patients with chronic obstructive pulmonary disease from healthy subjects

Besa V, Teschler H, Kurth I, Khan AM, Zarogoulidis P, Baumbach JI, Sommerwerck U, Freitag L, Darwiche K

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:399-406

Published Date: 23 February 2015

Efficient utilization of EBUS-TBNA samples for both diagnosis and molecular analyses

Oezkan F, Khan AM, Zarogoulidis P, Hohenforst-Schmidt W, Theegarten D, Yasufuku K, Nakajima T, Freitag L, Darwiche K

OncoTargets and Therapy 2014, 7:2061-2065

Published Date: 10 November 2014

Inhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment

Pitsiou G, Zarogoulidis P, Petridis D, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Papaiwannou A, Tsiouda T, Hohenforst-Schmidt W, Kakolyris S, Syrigos K, Huang H, Li Q, Turner JF, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:1753-1763

Published Date: 7 October 2014

Isothermal multiple displacement amplification: a methodical approach enhancing molecular routine diagnostics of microcarcinomas and small biopsies

Mairinger FD, Walter RFH, Vollbrecht C, Hager T, Worm K, Ting S, Wohlschläger J, Zarogoulidis P, Zarogoulidis K, Schmid KW

OncoTargets and Therapy 2014, 7:1441-1447

Published Date: 13 August 2014

Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol

Zarogoulidis P, Kioumis I, Lampaki S, Organtzis J, Porpodis K, Spyratos D, Pitsiou G, Petridis D, Pataka A, Huang H, Li Q, Yarmus L, Hohenforst-Schmidt W, Pezirkianidis N, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:1065-1072

Published Date: 12 August 2014

“Denervation” of autonomous nervous system in idiopathic pulmonary arterial hypertension by low-dose radiation: a case report with an unexpected outcome

Hohenforst-Schmidt W, Zarogoulidis P, Oezkan F, Mahnkopf C, Grabenbauer G, Kreczy A, Bartunek R, Darwiche K, Freitag L, Li Q, Huang H, Vogl T, LePilvert P, Tsiouda T, Tsakiridis K, Zarogoulidis K, Brachmann J

Therapeutics and Clinical Risk Management 2014, 10:207-215

Published Date: 27 March 2014

Clinical differences between H3N2 and H1N1 influenza 2012 and lower respiratory tract infection found using a statistical classification approach

Petridis D, Zarogoulidis P, Kallianos A, Kioumis I, Trakada G, Spyratos D, Papaiwannou A, Porpodis K, Huang H, Rapti A, Hohenforst-Schmidt W, Zarogoulidis K

Therapeutics and Clinical Risk Management 2014, 10:77-86

Published Date: 7 February 2014

Clinical experimentation with aerosol antibiotics: current and future methods of administration [Corrigendum]

Zarogoulidis P, Kioumis I, Porpodis K, Spyratos D, Tsakiridis K, Huang H, Li Q, Turner JF, Browning R, Hohenforst-Schmidt W, Zarogoulidis K

Drug Design, Development and Therapy 2014, 8:121-122

Published Date: 16 January 2014

The role of second-line chemotherapy in small cell lung cancer: a retrospective analysis

Zarogoulidis K, Boutsikou E, Zarogoulidis P, Darwiche K, Freitag L, Porpodis K, Latsios D, Kontakiotis T, Huang H, Li Q, Hohenforst-Schmidt W, Kipourou M, Turner JF, Spyratos D

OncoTargets and Therapy 2013, 6:1493-1500

Published Date: 22 October 2013

Clinical experimentation with aerosol antibiotics: current and future methods of administration

Zarogoulidis P, Kioumis I, Porpodis K, Spyratos D, Tsakiridis K, Huang H, Li Q, Turner JF, Browning R, Hohenforst-Schmidt W, Zarogoulidis K

Drug Design, Development and Therapy 2013, 7:1115-1134

Published Date: 2 October 2013

Vitamin D in asthma and future perspectives

Huang H, Porpodis K, Zarogoulidis P, Domvri K, Giouleka P, Papaiwannou A, Primikyri S, Mylonaki E, Spyratos D, Hohenforst-Schmidt W, Kioumis I, Zarogoulidis K

Drug Design, Development and Therapy 2013, 7:1003-1013

Published Date: 23 September 2013

Successful application of extracorporeal membrane oxygenation due to pulmonary hemorrhage secondary to granulomatosis with polyangiitis

Hohenforst-Schmidt W, Petermann A, Visouli A, Zarogoulidis P, Darwiche K, Kougioumtzi I, Tsakiridis K, Machairiotis N, Ketteler M, Zarogoulidis K, Brachmann J

Drug Design, Development and Therapy 2013, 7:627-633

Published Date: 24 July 2013

Immunomodifiers in combination with conventional chemotherapy in small cell lung cancer: a Phase II, randomized study

Zarogoulidis K, Ziogas E, Boutsikou E, Zarogoulidis P, Darwiche K, Kontakiotis T, Tsakiridis K, Porpodis K, Latsios D, Chatzizisi O, Karapantzos I, Li Q, Kyriazis G

Drug Design, Development and Therapy 2013, 7:611-617

Published Date: 23 July 2013

Intratumoral chemotherapy for lung cancer: re-challenge current targeted therapies

Hohenforst-Schmidt W, Zarogoulidis P, Darwiche K, Vogl T, Goldberg EP, Huang H, Simoff M, Li Q, Browning R, Turner FJ, Le Pivert P, Spyratos D, Zarogoulidis K, Celikoglu SI, Celikoglu F, Brachmann J

Drug Design, Development and Therapy 2013, 7:571-583

Published Date: 18 July 2013

Measurement of exhaled alveolar nitrogen oxide in patients with lung cancer: a friend from the past still precious today

Kallianos A, Tsimpoukis S, Zarogoulidis P, Darwiche K, Charpidou A, Tsioulis I, Trakada G, Porpodis K, Spyratos D, Panoutspoulos A, Veletza L, Kostopoulos K, Kostopoulos C, Karapantzos I, Tsakiridis K, Hohenforst-Schmidt W, Zarogoulidis K, Rapti A, Syrigos K

OncoTargets and Therapy 2013, 6:609-613

Published Date: 31 May 2013

New dilemmas in small-cell lung cancer TNM clinical staging

Zarogoulidis K, Latsios D, Porpodis K, Zarogoulidis P, Darwiche K, Antoniou N, Hohenforst-Schmidt W, Eleftheriadou E, Boutsikou E, Kontakiotis T

OncoTargets and Therapy 2013, 6:539-547

Published Date: 16 May 2013

Gastrointestinal stromal tumor mesenchymal neoplasms: the offspring that choose the wrong path

Machairiotis N, Kougioumtzi I, Zarogoulidis P, Stylianaki A, Tsimogiannis K, Katsikogiannis N

Journal of Multidisciplinary Healthcare 2013, 6:127-131

Published Date: 31 March 2013

Successful management of an inadvertent excessive treprostinil overdose

Hohenforst-Schmidt W, Hornig J, Friedel N, Zarogoulidis P, Zarogoulidis K, Brachmann J

Drug Design, Development and Therapy 2013, 7:161-165

Published Date: 21 March 2013

Pelvic schwannoma in the right parametrium

Machairiotis N, Zarogoulidis P, Stylianaki A, Karatrasoglou E, Sotiropoulou G, Floreskou A, Chatzi E, Karamani A, Liapi G, Papakonstantinou E, Katsikogiannis N, Courcoutsakis N, Machairiotis C

International Journal of General Medicine 2013, 6:123-126

Published Date: 8 March 2013

Docetaxel-carboplatin in combination with erlotinib and/or bevacizumab in patients with non-small cell lung cancer

Boutsikou E, Kontakiotis T, Zarogoulidis P, Darwiche K, Eleptheriadou E, Porpodis K, Galaktidou G, Sakkas L, Hohenforst-Schmidt W, Tsakiridis K, Karaiskos T, Zarogoulidis K

OncoTargets and Therapy 2013, 6:125-134

Published Date: 1 March 2013

Attitudes of asthmatic and nonasthmatic children to physical exercise

Dimitrakaki V, Porpodis K, Bebetsos E, Zarogoulidis P, Papaiwannou A, Tsiouda T, Tsioulis H, Zarogoulidis K

Patient Preference and Adherence 2013, 7:81-88

Published Date: 19 January 2013

Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions

Karanikas M, Machairiotis N, Zarogoulidis P, Stylianaki A, Courcoutsakis N, Mitrakas A, Touzopoulos P, Lyratzopoulos N, Kouklakis G, Spanoudakis M, Polychronidis A

OncoTargets and Therapy 2012, 5:433-438

Published Date: 12 December 2012

Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease?

Hohenforst-Schmidt W, Riedel A, Zarogoulidis P, Franke C, Gschwendtner A, Huang H, Machairiotis N, Dramba V, Zarogoulidis K, Brachmann J

Drug Design, Development and Therapy 2012, 6:385-389

Published Date: 10 December 2012

Pegylated liposomal doxorubicin in malignant pleural mesothelioma: a possible guardian for long-term survival

Zarogoulidis P, Mavroudi M, Porpodis K, Domvri K, Sakkas A, Machairiotis N, Stylianaki A, Tsiotsios A, Courcoutsakis N, Zarogoulidis K

OncoTargets and Therapy 2012, 5:231-236

Published Date: 27 September 2012

Clinical differences between influenza A (H1N1) virus and respiratory infection between the two waves in 2009 and 2010

Zarogoulidis P, Glaros D, Kioumis I, Terzi E, Porpodis K, Tsiotsios A, Kallianos A, Trakada G, Machairiotis N, Stylianaki A, Sakas A, Rapti A, Courcoutsakis N, Constantinidis TC, Maltezos E, Zarogoulidis K

International Journal of General Medicine 2012, 5:675-682

Published Date: 13 August 2012

Abdominal wall endometrioma mimicking an incarcerated hernia: a case report

Simoglou C, Zarogoulidis P, Machairiotis N, Porpodis K, Simoglou L, Mitrakas A, Esebidis A, Sarika E, Kouklakis G, Iordanidis A, Katsikogiannis N

International Journal of General Medicine 2012, 5:569-571

Published Date: 29 June 2012

Difficult airway and difficult intubation in postintubation tracheal stenosis: a case report and literature review

Zarogoulidis P, Kontakiotis T, Tsakiridis K, Karanikas M, Simoglou C, Porpodis K, Mitrakas A, Esebidis A, Konoglou M, Katsikogiannis N, Zervas V, Aggelopoulou C, Mikroulis D, Zarogoulidis K

Therapeutics and Clinical Risk Management 2012, 8:279-286

Published Date: 27 June 2012

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Zarogoulidis P, Chatzaki E, Porpodis K, Domvri K, Hohenforst-Schmidt W, Goldberg EP, Karamanos N, Zarogoulidis K

International Journal of Nanomedicine 2012, 7:1551-1572

Published Date: 22 March 2012

Health costs from hospitalization with H1N1 infection during the 2009–2010 influenza pandemic compared with non-H1N1 respiratory infections

Zarogoulidis P, Glaros D, Kontakiotis T, Froudarakis M, Kioumis I, Kouroumichakis I, Tsiotsios A, Kallianos A, Steiropoulos P, Porpodis K, Nena E, Papakosta D, Rapti A, Constantinidis TC, Kerenidi T, Panopoulou M, Trakada G, Courcoutsakis N, Fouka E, Zarogoulidis K, Maltezos E

International Journal of General Medicine 2012, 5:175-182

Published Date: 5 March 2012

A case of typical pulmonary carcinoid tumor treated with bronchoscopic therapy followed by lobectomy

Porpodis K, Karanikas M, Zarogoulidis P, Kontakiotis T, Mitrakas A, Esebidis A, Konoglou M, Domvri K, Iordanidis A, Katsikogiannis N, Courcoutsakis N, Zarogoulidis K.

Journal of Multidisciplinary Healthcare 2012, 5:47-51

Published Date: 16 February 2012

Fat embolism due to bilateral femoral fracture: a case report

Porpodis K, Karanikas M, Zarogoulidis P, Konoglou M, Domvri K, Mitrakas A, Boglou P, Bakali S, Iordanidis A, Zervas V, Courcoutsakis N, Katsikogiannis N, Zarogoulidis K

International Journal of General Medicine 2012, 5:59-63

Published Date: 16 January 2012

Williams–Campbell syndrome: a case report

Konoglou M, Porpodis K, Zarogoulidis P, Loridas N, Katsikogiannis N, Mitrakas A, Zervas V, Kontakiotis T, Papakosta D, Boglou P, Bakali S, Courcoutsakis N, Zarogoulidis K

International Journal of General Medicine 2012, 5:41-44

Published Date: 11 January 2012

Current surgical status of thyroid diseases

Touzopoulos P, Karanikas M, Zarogoulidis P, Mitrakas A, Porpodis K, Katsikogiannis N, Zervas V, Kouroumichakis I, Constantinidis TC, Mikroulis D, Tsimogiannis KE

Journal of Multidisciplinary Healthcare 2011, 4:441-449

Published Date: 14 December 2011

Pulmonary thromboendarterectomy after treatment with treprostenil in a chronic thromboembolic pulmonary hypertension patient: a case report

Porpodis K, Konoglou M, Zarogoulidis P, Kaimakamis E, Kontakiotis T, Papakosta D, Zervas V, Katsikogiannis N, Courcoutsakis N, Mitrakas A, Touzopoulos P, Karanikas M, Zarogoulidis K, Markopoulou A

International Journal of General Medicine 2011, 4:767-772

Published Date: 8 November 2011

Occupational chemical burns: a 2-year experience in the emergency department

Touzopoulos P, Zarogoulidis P, Mitrakas A, Karanikas M, Milothridis P, Matthaios D, Kouroumichakis I, Proikaki S, Pavlioglou P, Katsikogiannis N, Constantinidis TC

Journal of Multidisciplinary Healthcare 2011, 4:349-352

Published Date: 3 October 2011

Serratia pneumonia presenting as hemoptysis in a patient with sarcoidosis: a case report

Zarogoulidis P, Porpodis K, Konoglou M, Saroglou M, Mitrakas A, Matthaios D, Touzopoulos P, Archontogeorgis K, Koulelidis A, Zarogoulidis K, Tryfon S

International Journal of General Medicine 2011, 4:661-664

Published Date: 8 September 2011

Community-acquired pneumonia due to Legionella pneumophila, the utility of PCR, and a review of the antibiotics used

Paul Zarogoulidis, Ioanna Alexandropoulou, Gioulia Romanidou, et al

International Journal of General Medicine 2011, 4:15-19

Published Date: 6 January 2011

Readers of this article also read:

Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries

Cimino E, Linari S, Malerba M, Halimeh S, Biondo F, Westfeld M

Patient Preference and Adherence 2014, 8:1713-1720

Published Date: 12 December 2014

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Rituximab for managing acquired hemophilia A in a case of chronic neutrophilic leukemia with the JAK2 kinase V617F mutation

Imashuku S, Kudo N, Kubo K, Saigo K, Okuno N, Tohyama K

Journal of Blood Medicine 2012, 3:157-161

Published Date: 5 December 2012

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia

Rivka Yatuv, Micah Robinson, Inbal Dayan-Tarshish, et al

International Journal of Nanomedicine 2010, 5:581-591

Published Date: 6 August 2010