Back to Journals » International Journal of Nanomedicine » Volume 6

Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites

Authors Elsherbini AAM, Saber M, Aggag M, El-Shahawy A, Shokier HAA

Published 28 September 2011 Volume 2011:6 Pages 2155—2165

DOI https://doi.org/10.2147/IJN.S23952

Review by Single-blind

Peer reviewer comments 2

Alsayed AM Elsherbini1, Mahmoud Saber2, Mohamed Aggag2, Ahmed El-Shahawy2, Hesham AA Shokier1
1National Institute of Laser Enhanced Science, 2Children's Cancer Hospital, Cairo, Egypt

Introduction: The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency.
Methods: Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice.
Results: In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared.
Conclusion: This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.

Keywords: laser, hyperthermia, gold magnetic nanocomposites, Ehrlich carcinoma

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Lipid nanoparticles as delivery vehicles for the Parietaria judaica major allergen Par j 2

Bondì ML, Montana G, Craparo EF, Di Gesù R, Giammona G, Bonura A, Colombo P

International Journal of Nanomedicine 2011, 6:2953-2962

Published Date: 21 November 2011

Biosynthesis of gold nanoparticles using chloroplasts

Zhang YX, Zheng J, Gao G, Kong YF, Zhi X, Wang K, Zhang XQ, Cui DX

International Journal of Nanomedicine 2011, 6:2899-2906

Published Date: 21 November 2011

Embedded nanomicro syringe on chip for molecular therapy

Jalil MA, Suwanpayak N, Kulsirirat K, Suttirak S, Ali J, Yupapin PP

International Journal of Nanomedicine 2011, 6:2925-2932

Published Date: 18 November 2011

In-vivo imaging of oral squamous cell carcinoma by EGFR monoclonal antibody conjugated near-infrared quantum dots in mice

Yang K, Zhang FJ, Tang H, Zhao C, Cao YA, Lv XQ, Chen D, Li YD

International Journal of Nanomedicine 2011, 6:1739-1745

Published Date: 19 August 2011

Optimization of single-walled carbon nanotube solubility by noncovalent PEGylation using experimental design methods

Hadidi N, Kobarfard F, Nafissi-Varcheh N, Aboofazeli R

International Journal of Nanomedicine 2011, 6:737-746

Published Date: 8 April 2011

Time-dependent effect in green synthesis of silver nanoparticles

Darroudi M, Ahmad MB, Zamiri R, Zak A, Abdullah AH, Ibrahim NA

International Journal of Nanomedicine 2011, 6:677-681

Published Date: 5 April 2011

Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment

Silva AC, Oliveira TR, Mamani JB, Malheiros SMF, Malavolta L, Pavon LF, Sibov TT, Amaro E Jr, Tannús A, Vidoto ELG, Matins MJ, Santos RS, Gamarra LF

International Journal of Nanomedicine 2011, 6:591-603

Published Date: 25 March 2011

Laser-fabricated castor oil-capped silver nanoparticles

Reza Zamiri, Azmi Zakaria, Hossein Abbastabar, et al

International Journal of Nanomedicine 2011, 6:565-568

Published Date: 23 March 2011