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Large-cell neuroendocrine carcinoma of nasal cavity and paranasal sinuses after successful curative therapy: a case report and literature review

Authors Zhao Q, Wei J, Zhang C, Meng L, Wang B, Gao L, Jiang X

Received 18 November 2018

Accepted for publication 28 February 2019

Published 17 April 2019 Volume 2019:12 Pages 2975—2980

DOI https://doi.org/10.2147/OTT.S195052

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 4

Editor who approved publication: Dr XuYu Yang


Qin Zhao,1 Jinlong Wei,1 Chengbin Zhang,2 Lingbin Meng,3 Bin Wang,1 Ling Gao,1 Xin Jiang1

1Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 2Department of pathology, the First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 3Department of Internal Medicine, Florida Hospital, Orlando, FL 32804, USA

Abstract: This report describes a 40-year-old male patient with symptoms affecting the nasal sinuses including nasal obstruction and olfactory anesthesia. Magnetic resonance imaging demonstrated that the tumor eroded the adjacent bone and bilateral frontal lobes. The biopsy sample of the left nasal mass was processed for both H&E staining and immunohistological staining for various markers. The final histological examination showed large-cell neuroendocrine carcinoma with poor differentiation. After a general evaluation, the patient was staged as cT4bN0M0. The patient was treated by combined radiotherapy and chemotherapy. The treatment yielded almost complete remission, and after 10 months of follow-up, no distant organ metastasis or recurrence in the primary tumor region was detected.We report this rare case and review the current literature of this tumor.

Keywords: nasal cavity and paranasal sinuses carcinoma, large-cell neuroendocrine carcinoma, pathology, radiotherapy


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