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Lanreotide depot deep subcutaneous injection: a new method of delivery and its associated benefits

Authors Carmichael J

Received 27 October 2011

Accepted for publication 24 November 2011

Published 18 January 2012 Volume 2012:6 Pages 73—82

DOI https://doi.org/10.2147/PPA.S20783

Review by Single-blind

Peer reviewer comments 2

John D Carmichael
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Abstract: Acromegaly is a rare disease characterized by excessive growth hormone secretion, usually from a pituitary tumor. Treatment options include surgery, medical therapy, and in some cases, radiation therapy. Current medical therapy consists of treatment with somatostatin analog medications or a growth hormone receptor antagonist. There are two somatostatin analogs currently in use, octreotide and lanreotide. Both are supplied in long-acting formulations and are of comparable biochemical efficacy. Lanreotide is supplied in a prefilled syringe and is injected into deep subcutaneous tissue. Studies have been conducted to assess the efficacy of self- or partner administration, and have demonstrated that injection of lanreotide can be accomplished reliably and safely outside a physician's office. For patients who have achieved biochemical control with lanreotide, the FDA has recently approved an extended dosing interval. Selected patients may be able to receive the medication less frequently with injections of 120 mg administered every 6 or 8 weeks. This review focuses on the use of lanreotide in the treatment of acromegaly, the safety and efficacy of the drug, and the benefits afforded to patients because of unique aspects of the delivery of lanreotide.

Keywords: acromegaly, treatment, lanreotide, somatostatin analog, pituitary tumor

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