Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 5

Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors

Authors Izquierdo JL, Martinez A, Guzman E, Lucas P, Rodríguez JM

Published 8 November 2010 Volume 2010:5 Pages 387—394


Review by Single-blind

Peer reviewer comments 2

José Luis Izquierdo, Arturo Martínez, Elizabet Guzmán, Pilar de Lucas, José Miguel Rodríguez
Pulmonology Department, Hospital Universitario, Guadalajara, Spain; Pulmonology Department, Hospital Gregorio Marañón, Madrid, Spain

Abstract: The aim of our study is to determine whether chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic heart disease and whether this association is related with a greater prevalence of classical cardiovascular risk factors. Ours is a case-control cross-sectional study design. Cases were hospital patients with ischemic heart disease in stable phase, compared with control hospital patients. All patients underwent post-bronchodilator (PBD) spirometry, a standardized questionnaire, and blood analysis. COPD was defined as per GOLD PBD forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) < 0.70. In our series of patient cases (n = 204) and controls (n = 100), there were 169 men in the case group (83%) and 84 in the control group (84%). Ages were 67 and 64 years, respectively (P < 0.05). There were no significant differences by weight, body mass index (BMI), pack-years, leukocytes, or homocysteine. The abdominal perimeter was significantly greater in cases (mean 101 cm ± standard deviation [SD] 10 versus 96 cm ± 11; P < 0.000). Both groups also had significant differences by C-reactive protein (CRP), fibrinogen, and hemoglobin values. In univariate analysis, increased risks for cases to show with individual classical cardiovascular risk factors were seen, with odds ratio (OR) 1.86 and 95% confidence interval (CI) (1.04–3.33) for diabetes mellitus, dyslipidemia (OR 2.10, 95% CI: 1.29–3.42), arterial hypertension (OR 2.47, 95% CI: 1.51–4.05), and increased abdominal perimeter (OR 1.71, 95% CI: 1.06–2.78). Percent predicted PBD FEV1 was 97.6% ± 23% in the patient group and 104% ± 19% in the control group (P = 0.01), but the prevalence of COPD was 24.1% in cases and 21% in controls. Therefore, COPD was not associated with ischemic heart disease: at the crude level (OR 1.19, 95% CI: 0.67–2.13) or after adjustment (OR 1.14, 95% CI:0.57–2.29). In conclusion, COPD was not associated with ischemic heart disease. The greater prevalence of classical cardiovascular risk factors in COPD patients could explain the higher occurrence of ischemic heart disease in these patients.

Keywords: chronic obstructive pulmonary disease, cardiovascular disease, systemic inflammation, comorbidity

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Other article by this author:

Readers of this article also read:

Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-Ԑ-caprolactone nanofibers and growth factors for prevention of incisional hernia formation

Plencner M, East B, Tonar Z, Otáhal M, Prosecká E, Rampichová M, Krejčí T, Litvinec A, Buzgo M, Míčková A, Nečas A, Hoch J, Amler E

International Journal of Nanomedicine 2014, 9:3263-3277

Published Date: 9 July 2014

Long-term dynamics of death rates of emphysema, asthma, and pneumonia and improving air quality

Kravchenko J, Akushevich I, Abernethy AP, Holman S, Ross Jr WG, Lyerly HK

International Journal of Chronic Obstructive Pulmonary Disease 2014, 9:613-627

Published Date: 16 June 2014

Improving adherence with inhaler therapy in COPD

Suzanne C Lareau, Barbara P Yawn

International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:401-406

Published Date: 24 November 2010

Noninvasive ventilation: has Pandora’s box been opened?

Ari Manuel, Richard EK Russell, Quentin Jones

International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:55-56

Published Date: 24 February 2010

Development of the Lung Function Questionnaire (LFQ) to identify airflow obstruction

Barbara P Yawn, Douglas W Mapel, David M Mannino, et al

International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:1-10

Published Date: 17 December 2009

Management of invasive aspergillosis in patients with COPD: rational use of voriconazole

Florence Ader, Anne-Lise Bienvenu, Blandine Rammaert, et al.

International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:279-287

Published Date: 24 July 2009

Impact factor and its role in academic promotion

Richard Russell, Dave Singh

International Journal of Chronic Obstructive Pulmonary Disease 2009, 4:265-266

Published Date: 16 July 2009