Back to Journals » Vascular Health and Risk Management » Volume 8

Lack of a relationship between circulating gamma-glutamyltransferase levels and carotid intima media thickness in hypertensive and diabetic patients

Authors Nuti M, Spontoni P, Grigoratos C, Dell'Omo G, Balbarini A, Pedrinelli R

Received 10 February 2012

Accepted for publication 9 March 2012

Published 1 May 2012 Volume 2012:8 Pages 275—281


Review by Single-blind

Peer reviewer comments 3

Marco Nuti, Paolo Spontoni, Chrysanthos Grigoratos, Giulia Dell'Omo, Alberto Balbarini, Roberto Pedrinelli
Dipartimento Cardio Toracico e Vascolare, Università di Pisa, Pisa, Italy

Background: By increasing the intracellular prooxidant burden, gamma-glutamyltransferase (GGT) may accelerate atherosclerotic vascular disease. That noxious influence may be reflected by circulating enzyme levels, a correlate of cardiovascular risk factors, and a predictor of incident events. To evaluate this hypothesis, we tested the association between circulating GGT and common carotid intima-media thickness (CIMT), a surrogate index of systemic atherosclerotic involvement, in a large and well-characterized group of patients at risk of cardiovascular disease (CVD).
Patients: This study analyzed 548 patients with hypertension and/or diabetes and a widely prevalent history of CVD. Subjects with known hepatic disease and abnormal GGT values were excluded.
Methods: CIMT (B-mode ultrasonography) values were the mean of four far-wall measurements at both common carotids. Metabolic syndrome (MetS) was diagnosed according to National Cholesterol Education Program-Adult Treatment Panel III criteria. Due to inherent sex-related differences in GGT levels, the data were analyzed separately in males and females in samples dichotomized by the median.
Results: The age-adjusted CIMT values did not differ by GGT levels in males or females. In contrast, the carotid wall was consistently thicker in patients with a history of CVD and MetS independent of age and concurrent GGT values. In both sexes, GGT was associated with key components of the MetS such as triglycerides, fasting plasma glucose, and body mass index.
Conclusion: The data collected in this mixed group of hypertensive and/or diabetic patients with widely prevalent history of CVD do not support the concept of a direct pathophysiological link between GGT levels within reference limits and atherosclerotic involvement.

Keywords: gamma-glutamyltransferase, carotid intima-media thickness, atherosclerosis, metabolic syndrome

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man

Alessandra Del Fiorentino, Silvana Cianchetti, Alessandro Celi, Giulia Dell’Omo, Roberto Pedrinelli

Vascular Health and Risk Management 2009, 5:233-242

Published Date: 8 February 2009

Readers of this article also read:

Review of predialysis education programs: a need for standardization

Van den Bosch J, Warren DS, Rutherford PA

Patient Preference and Adherence 2015, 9:1279-1291

Published Date: 9 September 2015

Stroke and diabetic ketoacidosis – some diagnostic and therapeutic considerations

Jovanovic A, Stolic RV, Rasic DV, Markovic-Jovanovic SR, Peric VM

Vascular Health and Risk Management 2014, 10:201-204

Published Date: 8 April 2014

Lipid profiles and inflammatory markers after periodontal treatment in children with congenital heart disease and at risk for atherosclerosis

Bresolin AC, Pronsatti MM, Pasqualotto LN, Nassar PO, Jorge AS, Silva EA, Nassar CA

Vascular Health and Risk Management 2013, 9:703-709

Published Date: 11 November 2013

Perceptions of barriers to cardiac rehabilitation use in Brazil

Ghisi GLM, Santos RZ, Aranha EE, Nunes AD, Oh P, Benetti M, Grace SL

Vascular Health and Risk Management 2013, 9:485-491

Published Date: 30 August 2013

Persistent middle cerebral artery occlusion associated with lower body temperature on admission

Kvistad CE, Øygarden H, Thomassen L, Waje-Andreassen U, Naess H

Vascular Health and Risk Management 2013, 9:297-302

Published Date: 17 June 2013

Metabolic biomarkers for predicting cardiovascular disease

Montgomery JE, Brown JR

Vascular Health and Risk Management 2013, 9:37-45

Published Date: 29 January 2013

Mipomersen and other therapies for the treatment of severe familial hypercholesterolemia

Bell DA, Hooper AJ, Watts GF, Burnett JR

Vascular Health and Risk Management 2012, 8:651-659

Published Date: 28 November 2012

The potential benefit of stem cell therapy after stroke: an update

Banerjee S, Williamson DA, Habib N, Chataway J

Vascular Health and Risk Management 2012, 8:569-580

Published Date: 10 October 2012

Helicobacter pylori infection is identified as a cardiovascular risk factor in Central Africans

Longo-Mbenza B, Nsenga JN, Mokondjimobe E, Gombet T, Assori IN, Ibara JR, Ellenga-Mbolla B, Vangu DN, Fuele SM

Vascular Health and Risk Management 2012, 8:455-461

Published Date: 15 August 2012