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Keratoconus: current perspectives

Authors Vazirani J, Basu S

Received 18 June 2013

Accepted for publication 16 August 2013

Published 14 October 2013 Volume 2013:7 Pages 2019—2030

DOI https://doi.org/10.2147/OPTH.S50119

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Jayesh Vazirani, Sayan Basu

Cornea and Anterior Segment Services, LV Prasad Eye Institute, Hyderabad, India

Abstract: Keratoconus is characterized by progressive corneal protrusion and thinning, leading to irregular astigmatism and impairment in visual function. The etiology and pathogenesis of the condition are not fully understood. However, significant strides have been made in early clinical detection of the disease, as well as towards providing optimal optical and surgical correction for improving the quality of vision in affected patients. The past two decades, in particular, have seen exciting new developments promising to alter the natural history of keratoconus in a favorable way for the first time. This comprehensive review focuses on analyzing the role of advanced imaging techniques in the diagnosis and treatment of keratoconus and evaluating the evidence supporting or refuting the efficacy of therapeutic advances for keratoconus, such as newer contact lens designs, collagen crosslinking, deep anterior lamellar keratoplasty, intracorneal ring segments, photorefractive keratectomy, and phakic intraocular lenses.

Keywords: keratoconus, corneal topography, hydrops, collagen cross-linking, keratoplasty, contact lenses

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