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Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review

Authors Seedat RY

Received 6 October 2019

Accepted for publication 14 January 2020

Published 4 February 2020 Volume 2020:11 Pages 39—46

DOI https://doi.org/10.2147/PHMT.S200186

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Roosy Aulakh


RY Seedat

Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa

Correspondence: RY Seedat
Department of Otorhinolaryngology, Faculty of Health Science, University of the Free State, P.O. Box 339, Bloemfontein 9300, South Africa
Tel +27-51-4053344
Fax +27-51-4053102
Email seedatry@ufs.ac.za

Abstract: Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV), usually HPV types 6 and 11, which is characterized by recurrent papillomas of the respiratory tract, mainly the larynx. Patients usually present between the ages of 2 and 6 years. The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress. Treatment consists of repeated microlaryngoscopic procedures to remove the papillomas as there is no cure. The poor availability and accessibility of appropriate healthcare services in developing countries are barriers to the early diagnosis and appropriate management of patients with juvenile-onset recurrent respiratory papillomatosis (JoRRP), requiring many patients to have a tracheostomy. The introduction of prophylactic vaccines that include HPV6 and HPV11 is necessary in order to reduce the incidence of JoRRP.

Keywords: recurrent respiratory papillomatosis, human papillomavirus, children, developing countries

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