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Transplant Research and Risk Management
Chair, Department of Cancer Biology, Cleveland Clinic, Lerner Research Institute, United States
Qing Yi, MD, PhD, is Chair and Staff, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic.
Dr Yi is one of the leading investigators in the field of immune regulation and immunotherapy in multiple myeloma. He has been working on characterizing myeloma-specific T cells and their subsets, and examining their functions in relationship to myeloma tumor cells in both in vitro and in vivo experiments, and on identifying novel myeloma-associated antigens for immunotherapy. In addition, Dr Yi has been conducting clinical trials to evaluate the efficacy of immunizing patients with idiotype or dendritic cell-based vaccines. His research will continue focusing on the development of effective immunotherapy strategies to cure myeloma patients in combination with high-dose chemotherapy.
Recently, Dr Yi and his group discovered that anti-β2-microglublin antibodies could kill myeloma cells. His research team is thus examining whether these antibodies have therapeutic potentials to treat patients with myeloma. Furthermore, his recent studies demonstrate that C-reactive protein (CRP) protects myeloma cells from chemotherapy drug-induced apoptosis, and further work is under way to explore whether CRP can be targeted for myeloma therapy. Dr Yi’s research has been supported by US federal and foundation grants since 1998, and he has authored over 120 papers in the fields of myeloma research, immunotherapy of cancer, and tumor biology.
Honorary Editorial Board
Anthony Atala, Professor and Chief, Department of Urology, Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston Salem, NC, USA
James Blumenthal, Professor, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Clark K. Colton, Professor, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge , MA
Michel Delahousse, Head, Nephrology and Kidney Transplant Unit, Hopital Foch, Suresnes, France
Wayne Hancock, Professor and Chief, Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Josh Levitsky, Medicine and Surgery, Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL, USA
Mohammed Moghadasian, Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Frederic I. Preffer, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Camillo Ricordi, Professor, Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA
Paul Todd, Chief Scientist, Techshot, Inc., Greenville, IN, USA
Guido J. Tricot, Professor, Division of Hematology, Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT, USA
Lori J. West, Professor of Pediatrics, Surgery and Immunology, Director of Heart Transplantation Research, University of Alberta, Edmonton, Alberta, Canada
George Yung-Hsing Wu, Professor and Director, Hepatology Section, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA
Xiaoming Yang, Professor, Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA