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Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies

Authors Castillo J, Iyengar M, Kuritzky B, Bishop K

Received 5 October 2013

Accepted for publication 25 December 2013

Published 21 February 2014 Volume 2014:7 Pages 333—342

DOI https://doi.org/10.2147/OTT.S34641

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Jorge J Castillo,1 Meera Iyengar,2 Benjamin Kuritzky,2 Kenneth D Bishop2

1Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, 2Division of Hematology and Oncology, Rhode Island Hospital, Providence, RI, USA

Abstract: In the last decade, the advent of biological targeted therapies has revolutionized the management of several types of cancer, especially in the realm of hematologic malignancies. One of these pathways, and the center of this review, is the phosphatidylinositol-3-kinase (PI3K) pathway. The PI3K pathway seems to play an important role in the pathogenesis and survival advantage in hematologic malignancies, such as leukemia, lymphoma, and myeloma. The objectives of the present review, hence, are to describe the current knowledge on the PI3K pathway and its isoforms, and to summarize preclinical and clinical studies using PI3K inhibitors, focusing on the advances made in hematologic malignancies.

Keywords: phosphatidylinositol-3-kinase pathway, inhibitors, leukemia, lymphoma, myeloma

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