Back to Journals » Clinical Interventions in Aging » Volume 5

Is there an optimal management for localized prostate cancer?

Authors Singh J, Trabulsi EJ, Gomella L

Published 5 July 2010 Volume 2010:5 Pages 187—197

DOI https://doi.org/10.2147/CIA.S6555

Review by Single-blind

Peer reviewer comments 2

Jaspreet Singh , Edouard J Trabulsi, Leonard G Gomella

Department of Urology Kimmel Cancer Center Thomas Jefferson University Philadelphia, PA, USA

Abstract: Widespread screening with prostate-specific antigen (PSA) has led to a significant increase in the detection of early stage, clinically localized prostate cancer (CaP). Various ­treatment options for localized CaP are discussed in this review article including active ­surveillance, radical prostatectomy, radiation therapy, and cyrotherapy. The paucity of high-level evidence adds a considerable amount of controversy when choosing the “optimal” ­intervention, for both the treating physician and the patient. The long time course of CaP intervention outcomes, combined with continuing modifications in treatments, further complicate the ­matter. Lacking randomized trials that compare treatment options, this review article attempts to summarize the different treatment options and associated side-effects, including effects on health-related quality of life, from current published literature.

Keywords: prostate cancer, PSA, detection

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]