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Is Chikungunya Virus Infection an Independent Risk Factor for 2-Year Mortality in Older Afro-Caribbean Subjects?

Authors Godaert L, Nicolon C, Najioullah F, Kanagaratnam L, Césaire R, Dramé M

Received 14 March 2020

Accepted for publication 9 June 2020

Published 10 July 2020 Volume 2020:13 Pages 2223—2228


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Suresh Antony

Lidvine Godaert,1 Camille Nicolon,2 Fatiha Najioullah,3 Lukshe Kanagaratnam,4 Raymond Césaire,3,5 Moustapha Dramé5,6

1Department of Geriatrics, General Hospital of Valenciennes, Valenciennes, France; 2Department of Geriatrics, Hospital of Marennes, Marennes, France; 3Department of Virology, University Hospitals of Martinique, Fort-de-France, Martinique; 4Department of Research and Public Health, University Hospitals of Reims, Reims, France; 5Faculty of Medicine, University of French West Indies, Fort-de-France, Martinique; 6Department of Research and Innovation, University Hospitals of Martinique, Fort-de-France, Martinique

Correspondence: Moustapha Dramé
Department of Research and Innovation - CS 90632, University Hospitals of Martinique - Pierre Zobda-Quitman Hospital, Fort-de-France 97261, Martinique
Tel +596 596 559769

Purpose: The aim of this study was to investigate whether Chikungunya virus infection (CVI) was an independent risk factor for 2-year mortality in Afro-Caribbean subjects aged 65 years or older.
Patients and methods: A retrospective cohort study was performed from January 2014 to December 2016 in the University Hospital of Martinique. Subjects aged ≥ 65 years admitted to the hospital were included. Baseline characteristics and concurrent manifestations at admission were collected. Subjects were followed up by phone for 2 years.
Results: A total of 687 old Afro-Caribbean subjects (80.4± 8.0 years) were included: 467 positive for CVI (Chik+) and 220 negative for CVI (Chik-). During the follow-up, 180 (26.2%) died. The proportion of deaths was higher among Chik- (40.9%) than among Chik+ subjects (21.6%) (p< 0.0001). By multivariable analysis, when adjusted for age polyarthralgia, neurological troubles, cardiovascular disorders, absence of neutrophilia, thrombocytopenia, hypernatremia, and hospital stay, Chik+ subjects had significantly higher survival rates (HR: 0.58; 95% CI: 0.40– 0.85) than Chik- ones.
Conclusion: Within the two years following hospital admission of subjects aged ≥ 65 years or older, Chik+ subjects had significantly higher survival rates than Chik- ones.

Keywords: Chikungunya, survival, elderly people, hospital admission

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