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Is aerobic exercise training during hemodialysis a reliable intervention for autonomic dysfunction in individuals with chronic kidney disease? A prospective longitudinal clinical trial

Authors Morais MJD, de Abreu LC, Santana de Oliveira F, Pinheiro Bezerra IM, Raimundo RD, Paulo Martins Silva R, Valenti VE, Pérez-Riera AR

Received 25 January 2019

Accepted for publication 19 June 2019

Published 27 August 2019 Volume 2019:12 Pages 711—718

DOI https://doi.org/10.2147/JMDH.S202889

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Mauro José de Deus Morais,1–3 Luiz Carlos de Abreu,2–4 Fabiano Santana de Oliveira,1–3 Italla Maria Pinheiro Bezerra,2,3,5 Rodrigo Daminello Raimundo,3 Romeu Paulo Martins Silva,1 Vitor Engracia Valenti,6 Andrés Ricardo Pérez-Riera2,3

1Centro de Saúde e Desporto, Universidade Federal do Acre, Rio Branco, Acre, Brazil; 2Laboratório de Delineamento em Pesquisas e Escrita Científica, Centro Universitário Saúde ABC Santo André, São Paulo, Brazil; 3Laboratório de Delineamento em Pesquisas e Escrita Científica, Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Espirito Santo, Brazil; 4Graduate Entry Medical School, University of Limerick, Limerick V94 T9PX, Ireland; 5Escola Superior de Ciências da Santa Casa de Misericórdia, EMESCAM, Vitória, Brazil; 6Centro de Estudos do Sistema Nervoso Autônomo, State University of São Paulo, Marília, São Paulo, Brazil

Correspondence: Mauro José de Deus Morais
Centro de Saúde e Desporto, Universidade Federal do Acre, Rua Gumercindo, nº 292, Bairro: Universitário, Rio Branco 69.917.698, Acre, Brazil
Tel +55 6 899 971 6122
Email maurodedeus@outlook.com

Italla Maria Pinheiro Bezerra
Escola Superior de Ciências da Santa Casa de Misericórdia, EMESCAM, Bolsista Capes Brasil, Vitória, Rio Branco 69.915-900, Brazil
Tel +55 2 799 253 4941
Email italla.bezerra@emescam.br

Introduction: Physical exercises help in the rehabilitation and recovery of various diseases. Cardiovascular and hypertension problems are the main causes of people being affected by kidney problems, which as a consequence, affects the heart rate variability (HRV) of the individual. Physical activity developed in a well-planned and thorough way can be a component in the treatment of this problem.
Objective: We aimed to evaluate the effects of aerobic exercise intervention during hemodialysis on autonomic heart rate regulation in individuals with chronic kidney disease (CKD).
Methods: This was a longitudinal trial conducted in 19 CKD patients. The patients underwent three weekly sessions of aerobic exercise during hemodialysis for 30 mins for 12 weeks (three months).
Results: HRV was analyzed before and after the protocol training. Linear indices of HRV were not different between before and after the protocol training. Nonlinear HRV analysis indicated reduced values of determinism (p=0008, Cohen’s d=0.82) and entropy (p=003, Cohen’s d=0.84) after the training protocol.
Conclusion: In conclusion, aerobic exercise training during hemodialysis did not improve autonomic control of heart rate in CKD patients.

Keywords: autonomic nervous system, cardiovascular system, exercise, kidney diseases, renal dialysis

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