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Irreversible electroporation of hepatocellular carcinoma: patient selection and perspectives

Authors Zimmerman A, Grand D, Charpentier KP

Received 30 November 2016

Accepted for publication 19 January 2017

Published 13 March 2017 Volume 2017:4 Pages 49—58

DOI https://doi.org/10.2147/JHC.S129063

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Professor Ahmed O Kaseb


Asha Zimmerman,1 David Grand,2 Kevin P Charpentier1

1Department of Surgery, 2Department of Radiology, Rhode Island Hospital, Brown University, Providence, RI, USA

Abstract: Irreversible electroporation (IRE) is a novel form of tissue ablation that uses high-current electrical pulses to induce pore formation of the cell lipid bilayer, leading to cell death. The safety of IRE for ablation of hepatocellular carcinoma (HCC) has been established. Outcome data for ablation of HCC by IRE are limited, but early results are encouraging and suggest equivalency to the outcomes obtained for thermal ablation for appropriately selected, small (<3 cm) tumors. Long-term oncologic efficacy and histopathologic response data have not been published, and therefore, application of IRE for the treatment of HCC should still be viewed with caution.

Keywords: ablation, liver, tumors, IRE, hepatic

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