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Iridocorneal endothelial syndrome: clinical perspectives

Authors Walkden A, Au L

Received 20 October 2017

Accepted for publication 1 March 2018

Published 9 April 2018 Volume 2018:12 Pages 657—664

DOI https://doi.org/10.2147/OPTH.S143132

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Andrew Walkden,1,2 Leon Au1,2

1Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; 2Centre for Ophthalmology and Vision Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK

Abstract: This article aims to review the clinical management strategies available for the rare iridocorneal endothelial syndrome. The different clinical variations as well as the imaging techniques available to aid diagnosis are discussed. We then present the evidence available to help the reader to understand how the condition can be managed medically and also the important surgical aspects of treatment. This involves raised intraocular pressure management in addition to the visual management options of partial or full thickness keratoplasty. We hope that this review provides an exhaustive but also succinct review of the literature available on what is a rare and difficult condition to treat.

Keywords: iridocorneal endothelial syndrome, endothelial syndrome, Cogan-Reese syndrome, Chandler syndrome, progressive iris atrophy

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