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IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer

Authors Song J, Zhang N, Zhang L, Yi H, Liu Y, Li Y, Li X, Wu M, Hao L, Yang Z, Wang Z

Received 28 January 2019

Accepted for publication 21 March 2019

Published 18 April 2019 Volume 2019:14 Pages 2757—2772


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Mian Wang

Jiao Song,1,2 Ni Zhang,1,2 Liang Zhang,2,3 Hengjing Yi,2 Yi Liu,1,2 Yanxi Li,1 Xuelin Li,2,4 Meng Wu,2,5 Lan Hao,2,3 Zhu Yang,1 Zhigang Wang2,3

1Gynaecology and Obstetrics Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 2Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing Medical University, Chongqing 400010, People’s Republic of China; 3Ultrasound Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China; 4Geriatric Department, Chongqing General Hospital, Chongqing 400014, People’s Republic of China; 5Ultrasound Department, Zhongnan Hospital of Wuhan University, Hubei 430071, People’s Republic of China

Background and purpose: Surgery is regarded as the gold standard for patients with advanced ovarian cancer. However, complete surgical removal of tumors remains extremely challenging; fewer than 40% of patients are cured. Here, we developed a new modality of theranostics for ovarian cancer based on a near-infrared light-triggered nanoparticle.
Methods: Nanoparticles loading IR780 iodide on base of folate modified liposomes were prepared and used for theranostics of ovarian cancer. Tumor targeting of FA-IR780-NP was evaluated in vitro and in an ovarian xenograft tumor model. A fluorescence stereomicroscope was applied to evaluate the tumor recognition of FA-IR780-NP during surgery. FA-IR780-NP mediated photothermal therapy effect was compared with other treatments in vivo.
Results: FA-IR780-NP was demonstrated to specifically accumulate in tumors. IR780 iodide selectively accumulated in tumors; the enhanced permeability and retention effect of the nanoparticles and the active targeting of folate contributed to the excellent tumor targeting of FA-IR780-NP. With the aid of tumor targeting, FA-IR780-NP could be used as an indicator for the real-time delineation of tumor margins during surgery. Furthermore, photothermal therapy mediated by FA-IR780-NP effectively eradicated ovarian cancer tumors compared with other groups.
Conclusion: In this study, we present a potential, effective approach for ovarian cancer treatment through near-infrared fluorescence image-guided resection and photothermal therapy to eliminate malignant tissue.

Keywords: ovarian cancer, imaged-guide surgery, IR780 iodide, photothermal therapy, nanomedicine

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